滨州医学院学报2016，Vol.39Issue(6)：401-403,452,4.
卵巢黄体表达的 kisspeptin／kiss1r 系统在自然流产大鼠发病中的作用
The function of kisspeptin/kiss1 r system expressed in the corpus luteum during the pathogenesis of spontaneous abortion rats
寇连翠 1骆倩倩 2时彦 3李红星 1张洪芹1
作者信息
- 1. 滨州医学院基础医学院组织学与胚胎学教研室烟台 264003
- 2. 东营市人民医院胸心外科
- 3. 滨州医学院实验教学管理中心形态学实验室
- 折叠
摘要
Abstract
Objective To observe the changes of kisspeptin/kiss1r system expression in corpus luteum and to explore the role of kisspeptin/kiss1r system on the pathogenesis of spontaneous abortion .Methods The spontaneous abortion rat model was constructed with bromocriptine and serum progesterone ,estrogen ,luteinizing hormone levels were detected by ELISA .Morpho‐logical changes of ovarian corpus luteum and the expression of kisspeptin/kiss1r were observed by H‐E staining and immuno histochemistry ,respectively .Results Compared with the pregnancy group ,the rate of abortion was significantly increased and serum progesterone level as well as estrogen was significantly reduced in the abortion rats .Volume of corpus luteum was signifi‐cantly reduced observed by H‐E staining and the number of capillaries and kisspeptin/kiss1r positive cells in the ovary was sig‐nificantly reduced during the abortion group .Conclusion The kisspeptin/kiss1r system expressed in the corpus luteum of abor‐tion model play its regulatory role on incretion by altering the body's hormone levels .It will be used as an experimental basis for discussing the pathogenesis and treatment of abortion in the future .关键词
kisspeptins/黄体/自然流产Key words
kisspeptins/corpus luteum/spontaneous abortion分类
医药卫生引用本文复制引用
寇连翠,骆倩倩,时彦,李红星,张洪芹..卵巢黄体表达的 kisspeptin／kiss1r 系统在自然流产大鼠发病中的作用[J].滨州医学院学报,2016,39(6):401-403,452,4.
