广西科学院学报2016，Vol.32Issue(4)：258-262,266,6.DOI:10.13657/j.cnki.gxkxyxb.20161123.001
海洋细菌Bacillus sp.753的次生代谢产物分析
Analysis of the Secondary Metabolites of Marine Bacte-rium Bacillus sp.753
摘要
Abstract
[Objective]To investigate the secondary metabolites of marine bacterium Bacillus sp.753 by various modern spectrum methods.[Methods]Constituents in the fermentation liq-uid of the marine bacteria were isolated and purified by silica gel,Sephadex LH-20,and semi-preparative reverse-phase HPLC (C18 ).Their structures were identified by NMR,MS and lit-eratures.[Results]Twelve compounds were iso-lated from marine bacterium Bacillus sp.753 and their structures were identified as uridine (1 ), thymine (2),cyclo-(phe-lle)(3),cyclo-(ala-pro) (4),cyclo-(val-pro)(5),cyclo-(pro-leu)(6),cy-clo-(phe-pro)(7),cyclo-(tyr-pro)(8),cyclo-(tyr-4-hydroxy-pro)(9),cyclo-(leu-pro)(10), cyclo-(pro-4-hydroxyl-lle)(11),cyclo-(D-pipecolinyl-L-leucine)(12).[Conclusion]Com-pounds 1~1 2 were isolated from this bacterium for the first time,which not only enriched the types of chemical composition in the Bacillus sp.753,but also increased the research val-ue of the marine bacterium.关键词
海洋细菌/Bacillus sp.753/化学成分/结构鉴定Key words
marine bacterium/Bacillus sp.753/chemical constituents/structure identification分类
医药卫生引用本文复制引用
孙玉林,杨梅语,辛欣欣,甘文恒,龚珍英,李玲,邓文英,刘晓,陈道海..海洋细菌Bacillus sp.753的次生代谢产物分析[J].广西科学院学报,2016,32(4):258-262,266,6.基金项目
岭南师范学院博士启动项目(ZL1313),广东省自然科学基金项目(2015A030310406),湛江海鲜食材资源可持续利用与保护科技服务平台项目(2014B040404071)和湛江海鲜食材资源可持续利用重点实验室项目(2015A06008)资助。 （ZL1313）
