广西科学院学报2016，Vol.32Issue(4)：282-287,6.DOI:10.13657/j.cnki.gxkxyxb.20161201.002
凡纳滨对虾体内大黄苷的药代动力学特征
Pharmacokinetic Characteristics of Rhein in the Body of Penaeus vannamei
摘要
Abstract
[Objective]The absorption,distribution and metabolism of rhein in Penaeus vannamei were studied,and the clinical dosing regimen was established.[Methods]We ana-lysed the pharmacokinetics of rhein in Penaeus vannamei,blood,hepatopancreas,muscle and gill were sampled after muscle inj ecting with a single dose of rhein (5 mg/kg),the contents of rhein was determined by HPLC,and 3P87 software were used to analyse the data process-ing.[Results]Rhein in four kinds of tissue in the peak time (Tmax)early and were 0.17 h,2. 73 h,0.44 h,0.23 h;elimination half-life (T 1/2Ke)short were 2.13 h,2.36 h,3.12 h,3.72 h;in compartment model choice,the four organizations rhein optimum pharmacokinetic model are suitable for a one-compartment model.[Conclusion]Rhein after intramuscular inj ection, the drug vannamei tissues peak time is short,wide distribution,rapid absorption,strong scav-enging ability.The concentration of rhein vannamei gills is high,which provides a theoretical basis for using it to treat gill disease of Penaeus vannamei.关键词
大黄苷/凡纳滨对虾/药代动力学/高效液相色谱Key words
rhein/Penaeus vannamei/pharma-cokinetics/HPLC分类
农业科技引用本文复制引用
盖春蕾,张元发,叶海斌..凡纳滨对虾体内大黄苷的药代动力学特征[J].广西科学院学报,2016,32(4):282-287,6.基金项目
国家虾产业技术体系项目(编号CARS-47)资助。 （编号CARS-47）
