护理学报2016，Vol.23Issue(23)：11-15,5.DOI:10.16460/j.issn1008-9969.2016.23.0011
化疗致周围神经病变患者跌倒和近乎跌倒的危险因素分析
Risk Factors of Falls and Near Falls in Cancer Patients with Chemotherapy-induced Peripheral Neuropathy
摘要
Abstract
Objective To evaluate the possible risk factors for falls and near falls in patients with chemotherapy-induced peripheral neuropathy (CIPN). Methods The cross sectional, descriptive study included patients who had received neurotoxic chemotherapy and reported at least one symptom of peripheral neuropathy. Questionnaires including the Chinese version of Chemotherapy-Induced Peripheral Neuropathy Assessment Tool, HADS and a demographic survey were administered. Data were analyzed using descriptive statistics and logistic regression. Results In this sample (n=179), 30 patients had falls and near falls. Univariate logistic regression analysis identified potential risk factors for falls and near falls in patients with CIPN including depression, neuropathic pain, number of neuropathic symptoms, score of sensory/ motor neuropathy, severity of CIPN, CIPN experience and interference with activity of daily life, total score of Chemotherapy-Induced Peripheral Neuropathy Assessment Tool, severity of loss of balance and muscle weakness, as well as self-reported interference with walking. Multivariate logistic regression analysis showed number of neuropathic symptoms (OR=1.318,P=0.031), severity of loss of balance (OR=1.298,P=0.028)and interference with walking (OR=1.239,P=0.021) were independently associated with falls and near falls. Conclusion Patients with CIPN who reported more neuropathic symptoms, those with CIPN interfering with walking and those having trouble with balance may be at a higher risk of falls. To reduce the risk of falls or near falls, it is necessary to not only assess the symptoms of CIPN, but also provide balance and activity training. Recommendations in terms of aids and security environment at home for patients undergoing neurotoxic chemotherapy are also helpful to reduce the risk of falls.关键词
化疗导致的周围神经病变/跌倒/近乎跌倒Key words
chemotherapy-induced peripheral neuropathy/falls/near falls分类
医药卫生引用本文复制引用
王悦,白燕妮,王美霞,杨艳,丁艳妮,赵卿,付菊芳..化疗致周围神经病变患者跌倒和近乎跌倒的危险因素分析[J].护理学报,2016,23(23):11-15,5.基金项目
陕西省社发攻关项目 （）
