北华大学学报（自然科学版）2017，Vol.18Issue(1)：43-45,3.DOI:10.11713/j.issn.1009-4822.2017.01.009
跨膜蛋白超家族TM9 SFI和炎性反应介质在颅内动脉瘤壁形成和破裂中的作用分析
Analysis on the Effects of Transmembrane Protein Superfamily Proteins and Inflammatory Reaction Media on the Formation and Rupture of Intracranial Aneurysm
摘要
Abstract
Objective To investigate the role of transmembrane protein superfamily protein TM9 SFl and inflammatory reaction medium AZUl in the formation and rupture of intracranial aneurysm. Method 40 patients accepted intracranial aneurysm clip occlusion in our hospital were enrolled in this study. Superficial temporal artery of the patients during the operation was taken as the control group,and the upper total vascular wall was taken as the research group. The expression and content of TM9SFl and AZUl in ruptured aneurysm and superficial temporal artery were analyzed by Immuno histochemistry and Wsetern blot method. Results The results of Immuno histochemical staining showed that TM9 SFl and AZUl were negative or weakly positive expression in the control group,and showed positive or strong positive expression in the study group. The dying grades of AZUl and TM9SFl in the research group was 1. 90 ± 0. 20,2. 90 ±0. 30,respectively,significantly higher than in the control group with 0. 70 ± 0. 20,0. 80 ±0. 10,respectively(P<0. 05). Wsetern blot showed that the expression level of TM9SFl with 0. 95±0. 43 in the study group was significantly higher than that of the control group with 0 . 41 ± 0 . 15 ( P<0 . 05 ) . The expression of AZUl with 1 . 16+0 . 48 in the study group was significantly higher than that of the control group with 0. 39±0. 13(P<0. 05). Conclusion The high expression of TM9 SFl and AZUl is involved in the mechanism of protein degradation and inflammatory reaction in the process of the formation and rupture of intracranial aneurysms.关键词
跨膜蛋白超家族蛋白/炎性反应介质/颅内动脉瘤/破裂Key words
transmembrane protein superfamily protein/inflammatory reaction media/intracranial aneur-ysm/rupture分类
医药卫生引用本文复制引用
张明铭,蒋宇钢..跨膜蛋白超家族TM9 SFI和炎性反应介质在颅内动脉瘤壁形成和破裂中的作用分析[J].北华大学学报（自然科学版）,2017,18(1):43-45,3.基金项目
国家自然科学基金项目(81571156) （81571156）
湖南省科技厅科技计划项目(2014FJ4260) （2014FJ4260）
