北华大学学报（自然科学版）2017，Vol.18Issue(1)：53-56,4.DOI:10.11713/j.issn.1009-4822.2017.01.012
乳腺癌患者细胞免疫指标的检测及意义
Detection on Cellular Immunity and Its Clinical Significance in Patients with Breast Cancer
摘要
Abstract
Objective To detect the total number of T lymphocytes and the percentage of T lymphocyte subsets in the peripheral blood,such as CD4+T,CD8+T,CD45RA+T,and CD45RO+T cells in breast cancer patients,for the evaluation of the patients ’ immune status, and elucidate its clinical significance. Method 50 female patients with primary breast cancer were selected as case group and further divided into groups based on the TNM staging results obtained by the pathologic examination,including 27 cases of stage I breast cancer and 23 cases of stage II+III breast cancer;40 healthy women were selected as control group. A flow cytometry was used to detect the number of T lymphocyte subsets in the peripheral blood in each group, and the differences in the results between groups were statistically analyzed. Results CD3+T and CD4+T cell percentages in stage II+III breast cancer were significantly lower than those in the normal control group and stage I breast cancer group (P<0. 05);the percentage of CD45 RA+T cells in stage I breast carcinoma group was significantly lower than that in the normal control group and the percentage of CD45 RO+T cells in stage II+III breast cancer group was significantly lower than that in stage I breast cancer group ( P<0 . 05 );the percentage of CD45 RO+T cells in stage I breast cancer group was significantly higher than that in the normal control group and the percentage of CD45 RO+T cells in stage II+III breast cancer group was significantly higher than that in stage I breast cancer group ( P<0 . 05 ) . Conclusion T cell subsets detection is an important indicator for evaluating the immune function in patients with tumors,with important values in the clinical application. The occurrence,development and clinical stage of breast cancer have a certain correlation with the patients’ immune function in certain. As the disease develops, the body immune function showed a downward trend.关键词
乳腺癌/T淋巴细胞亚群/初始T细胞/记忆T细胞Key words
breast cancer/T lymphocyte subsets/naïve T cells (CD45RA+T cells)/memory T cells (CD45RO+T cells)分类
医药卫生引用本文复制引用
王文慧,李海滨,宋玉国..乳腺癌患者细胞免疫指标的检测及意义[J].北华大学学报（自然科学版）,2017,18(1):53-56,4.基金项目
吉林省教育厅科学技术研究项目(2013179) （2013179）
