北华大学学报（自然科学版）2017，Vol.18Issue(1)：57-61,5.DOI:10.11713/j.issn.1009-4822.2017.01.013
冠脉斑块CT值改变及血清炎性因子与冠脉斑块稳定性的相关研究
On CT Value Changes of Coronary Plaque and Serum Inflammatory Factors and Stability of Coronary plaque
摘要
Abstract
Objective The study was to detect CT value of coronary artery plaque by applying 128-slice spiral computed tomography coronary angiography ( 128-SCTA ) and examing inflammatory cytokine including high-sensitivity C-reactive protein ( Hs-CRP ) , interleukin-6 ( IL-6 ) and matrix metalloproteinases-9 ( MMP-9 ) in order to evaluate the vulnerability of coronary artery plaque. Method One hundred patients with coronary heart disease were divided into unstable angina pectoris ( UAP ) group and stable angina pectoris ( SAP ) group. The patients were examined by 128-slice spiral computed tomography coronary angiography. According to CT value, coronary artery plaques were divided into vulnerable plaque ( CT value<60 Hu ) , mix plaqu ( CT value 60-129 Hu) ,and hard plaque ( CT value>130 Hu) . The blood specimen were colleted from all the patients. The levels of hs-CRP,IL-6 and MMP-9 were examined. Results 1) The levels of hs-CRP,IL-6 and MMP-9 of UAP group were significantly higher than those of SAP group ( P<0 . 01 ) . 2 ) According to the results of all kinds of plague distribution,the vulnerable plaque accounted for 52. 9% in UAP group and hard plaque accounts for 17. 6%,that showing that the former was significantly higher than the latter. Vulnerable plaque accounts for 19. 4% in SAP group,hard plaque group accounts for 51. 6%, that showing that the latter was significantly higher than the former. Vulnerable plaque in UAP group was significantly higher than that of SAP group(P<0. 001). 3)The linear correlation between CT value and inflammatory factors showed that:hs-CRP , IL-6 and MMP-9 were negatively related with plaque CT value ( P<0 . 01 ) . Conclusion 128-SCTA may be employed to assess the morphology of coronary artery plaque to determine vulnerable plaque, mix plaque and hard plaque. 128-SCTA combining hs-CRP,IL-6 and MMP-9 make the inspection of vulnerable plaques coronary more accurately,which supply a safer,simpler and non-invasive method for CHD patients to find earlier vulnerable plaques.关键词
冠脉CTA/易损斑块/炎性因子/hs-CRP/IL-6/MMP-9Key words
coronary CTA/vulnerable plaque/inflammatory factor/hs-CRP/IL-6/MMP-9分类
医药卫生引用本文复制引用
郭华涛,徐丽华,常征利,王智,陈晓丽,常哲兴..冠脉斑块CT值改变及血清炎性因子与冠脉斑块稳定性的相关研究[J].北华大学学报（自然科学版）,2017,18(1):57-61,5.基金项目
吉林省教育厅科学技术研究项目(2012146) （2012146）
