成都大学学报（自然科学版）2016，Vol.35Issue(4)：317-320,334,5.
阿哌沙班片溶出度测定方法研究
Study on Dissolution Determination Method of Apixaban
郭兆元 1聂忠莉 2胡一冰 2曾吉 2王晓玲 3叶丁 3张勇 3萧茂玲 3郭瑞3
作者信息
- 1. 成都大学四川抗生素工业研究所，四川成都 610052
- 2. 成都大学药学与生物工程学院，四川成都 610106
- 3. 成都克莱蒙医药科技有限公司，四川成都 610041
- 折叠
摘要
Abstract
The paper is going to establish a method of dissolution determination of Apixaban .The establish-ment of the determination method for dissolution of Apixaban tablets is based on High Performance Liquid Chromatography .Phosphate buffer solution of 0.1% CTAB-pH 6.8 is used as dissolution medium which is degassed at 37 ± 0.5 ℃ ,with the rotate speed of 75 r/min and the sampling time of 30 min .The results show that the dissolution of six batches of test samples and reference drug is over 80% in 30 min .It is in compliance with the regulations .The method can be used to determine the dissolution of Apixaban tablets with its selective ,sensitive and accurate traits .关键词
阿哌沙班片/溶出度/高效液相色谱法Key words
Apixaban tablets/dissolution/High Performance Liquid Chromatography (HPLC)分类
医药卫生引用本文复制引用
郭兆元,聂忠莉,胡一冰,曾吉,王晓玲,叶丁,张勇,萧茂玲,郭瑞..阿哌沙班片溶出度测定方法研究[J].成都大学学报（自然科学版）,2016,35(4):317-320,334,5.
