福建农业学报2016，Vol.31Issue(10)：1028-1033,6.DOI:10.19303/j.issn.1008-0384.2016.10.005
乙酰甲喹在美洲鳗鲡体内的药物代谢动力学及残留研究
Pharmacokinetics and Residues of Mequindox in American Eel
摘要
Abstract
In the tank with a constant water temperature of 25 ± 1℃,American eels were administered with mequindox (MEQ)for the study.The eels were either orally fed with a feed at a single MEQ dosage rate of 120 mg/kg,or placed in a water bath containing 5 mg MEQ/L for 1 8 h.Samples were collected periodically to obtain MEQ concentrations in the blood plasma, muscle, liver, and kidney of the eels by HPLC, while MEQ pharmacokinetics analyzed.The pharmacokinetic characteristics of MEQ were found to be fast absorbed,evenly distributed,rapidly eliminated, and left with low residues in the fish. Under the oral administration, the pharmacokinetics of the blood plasma showed a Tmax at 0.75 h,Cmax at 4 115μg·L-1 ,T1/2 at 7.40 h,and CL/F at 41.89 L·kg-1 ·h-1 .The concentrations of MEQ in the organs were below the detectable level after 72 h.For the medicated bath treatment,the pharmacokinetics of the eel blood plasma indicated Tmax to be 0.25 h,Cmax 435.6μg· L-1 ,T1/2 0.26 h,and CL/F 1.241 L·kg-1 ·h-1 .The MEQ in the organs became not detectable after 2.5 h.The distribution of plasma MEQ in the eels under either treatment fitted the one-compartment open model.关键词
乙酰甲喹/美洲鳗鲡/药代动力学/高效液相色谱Key words
mequindox/american eel/pharmacokinetics/high performance liquid chromatography分类
农业科技引用本文复制引用
潘葳,刘文静..乙酰甲喹在美洲鳗鲡体内的药物代谢动力学及残留研究[J].福建农业学报,2016,31(10):1028-1033,6.基金项目
福建省科技计划项目---省属公益类科研院所基本科研专项(2014R1025-3) （2014R1025-3）
