口腔疾病防治2017，Vol.25Issue(1)：31-36,6.DOI:10.12016/j.issn.2096-1456.2017.01.006
双膦酸盐类药物相关性颌骨坏死临床研究
Clinical study of bisphosphonate-related osteonecrosis of the jaws
摘要
Abstract
Objective To understand the pathogenesis of bisphosphonate⁃related osteonecrosis of the jaws (BRONJ) and to investigate its differential diagnosis, clinical manifestations, treatment and prevention. Methods By analyzing the clinical data of 4 patients with BRONJ in the retrospective study with reviewing related literatures in the world to make a summary of it. Results Cases of 4 patients mainly presented recurring pain, discharging of pus and disposure and necrosis of the bone. 3 patients received surgical and antibiotics treatments, one of them had local infection which was under control by oral antibiotic. The other 2 patients had no infection and recurrence. Conclusion BRONJ is caused by jaw necrosis due to bisphosphonate inhibition of osteoclast function. For the reason that none of the treat⁃ments is unified and satisfied, we should focus on the risk factors in prevention. Appropriate surgery treatment could be well controlled the process of the BRONJ which should be popularization in our study.关键词
双膦酸盐/颌骨/骨坏死/感染/治疗Key words
Biophosphonate/Jaw/Osteonecrosis/Infection/Treatment分类
医药卫生引用本文复制引用
吴宇翎,赵小朋,严凌健,潘朝斌..双膦酸盐类药物相关性颌骨坏死临床研究[J].口腔疾病防治,2017,25(1):31-36,6.基金项目
广东省科技计划（2012B031800252）；高等学校博士学科点专项基金课题 （）
