临床与病理杂志2016，Vol.36Issue(12)：1961-1964,4.DOI:10.3978/j.issn.2095-6959.2016.12.013
非小细胞肺癌胸水细胞块ALK融合基因检测分析
Analysis of cell blocksALK fusion gene in pleural effusion of non-small cell lung cancer
摘要
Abstract
Objective: To investigate the clinical value of the cell blacks for anaplastic lymphoma kinase (ALK) fusion gene detection in non-small cell lung cancer (NSCLC).Methods: 215 cases of cell block from pleural effusion of non-small cell lung cancer were collected. hTree types ofALK fusion and 404 cases of tissue block were detected by ARMS-PCR method. hTe consistency ofALK fusion was examined in 74 cases of patients with tissue block and cell block.Results:ALK fusion was found in 26 of 215 cell blocks, the positive detection rate was 12.09%.ALK fusion was detected in 25 of 404 tissue blocks, the positive detection rate was 6.19%. 67 cases in the 74 (90.54%) cases had the same result as tissue block.ALK fusion was detected in 11 of 74 (14.86%) cell blocks, and 14 of 74 (18.92%) tissue blocks.Conclusion: hTe rate ofALK fusion in cell blocks of non-small cell lung cancer is higher than that in matched tissue blocks. hTe patients with malignant pleural effusion are likely to tend toALK fusion.关键词
肺肿瘤/非小细胞肺癌/细胞块/间变性淋巴瘤激酶Key words
lung neoplasm/non-small cell lung cancer/cell block/ALK引用本文复制引用
朱礼阳,徐建平,于忠和,赵洁婷,叶伟,朱东波,孙晓,宋蓉蓉,许春伟..非小细胞肺癌胸水细胞块ALK融合基因检测分析[J].临床与病理杂志,2016,36(12):1961-1964,4.基金项目
国家自然科学基金(81372489)，北京市科技计划课题(2131100006813032)。This work was supported by the National Natural Science Foundation of China (81372489), Beijing Municipal Science and Technology Plan Project (2131100006813032), P. R. China （81372489）
