基础医学与临床2017，Vol.37Issue(1)：67-70,4.
SH2B3基因标签单核苷酸多态性与汉族原发性高血压的关系
Association of SH2 B3 gene tag single nucleotide polymorphisms with essential hypertension in Han population
摘要
Abstract
Objective To assess the association of tag single nucleotide polymorphisms ( tag SNPs) of SH2B adap-tor protein 3 ( SH2 B3 ) gene with essential hypertension ( EH ) in Han population .Methods Six tag SNPs ( rs7309325 , rs11065898 , rs10849947 , rs2239196 , rs2238154 and rs739496 ) were genotyped in 510 patients with EH and 510 healthy controls using polymerase chain reaction-restriction fragment length polymorphism method ( PCR-RFLP) .Results Compared to CC genotype , the T allele carriers of rs2239196 were more likely to be hy-pertensive ( OR=2.59 ,95%CI 1.36-4.96 ,Bonferroni correction P<0.05 ) .Conclusions The rs2239196 T al-lele is potential a risk factor of EH in Han population .关键词
原发性高血压/SH2B3基因/标签SNPs/汉族Key words
essential hypertension/SH2B3/tag SNPs/Han population分类
医药卫生引用本文复制引用
吴艳瑞,罗兰,杨本官,肖春杰..SH2B3基因标签单核苷酸多态性与汉族原发性高血压的关系[J].基础医学与临床,2017,37(1):67-70,4.基金项目
云南省应用基础研究计划（2014FB005）；云南省教育厅科学研究基金（2013Y288）；昆明医科大学基础医学院博士启动基金 （）
