计算机工程与应用2017，Vol.53Issue(1)：23-28,6.DOI:10.3778/j.issn.1002-8331.1605-0377
基于正则化的混合准则放疗规划模型的改进
Improvement based on regularization for building hybrid crite-ria model of radiotherapy planning
摘要
Abstract
To solve the problem existing in the physical-biological hybrid criteria model based on the generalized equiva-lent uniform dose linear objective function in conformal intensity-modulated radiation therapy, this paper presents a smooth and convex regularization of max function using regularization theory, and improves the hybrid criteria model based on the generalized equivalent uniform dose. When this improved model is applied in inverse planning optimization process, problems(searching ability of optimization algorithm is restricted and it is hard time predicting how large a step can be made when using a gradient-based optimization algorithm)existing in original model are circumvented. Compared to the original model, experiments show that the method using newly proposed model can get better protection to organs at risk while ensuring similar dose coverage for target and the quality of radiotherapy planning is improved.关键词
调强放疗/等效均匀剂量/混合准则/正则化Key words
intensity-modulated radiation therapy/generalized equivalent uniform dose/hybrid criteria/regularization分类
信息技术与安全科学引用本文复制引用
郭彩萍,舒华忠,桂志国,张鹏程..基于正则化的混合准则放疗规划模型的改进[J].计算机工程与应用,2017,53(1):23-28,6.基金项目
国家自然科学基金（No.61271312）；山西省回国留学人员科研资助项目（No.2016-091）。 （）
