中国临床保健杂志2017，Vol.20Issue(1)：14-16,3.DOI:10.3969/J.issn.1672-6790.2017.01.005
左旋甲状腺素对甲状腺功能减退症患者脑默认网络静息态功能连接的影响
The effect of levothyroxine treatment on resting-state brain functional connectivity of default network in patients with hypothyroidism
摘要
Abstract
Objective To study the state of resting-state brain functional connectivity of default network in pa-tients with hypothyroidism,and the value of levothyroxine replacement treatment.Method The strength of the resting-state brain functional connectivity of default network in 1 4 patients with newly diagnosed adult hypothyroidism and 1 5 healthy controls before and after the treatment of levothyroxine was detected using resting-state functional magnetic reso-nance(rsfMRI).Results Using the method based on the seed analysis,there was no significant differences between the two scans in the normal control group,but there was a significant decrease of the strength of the brain functional connec-tivity of default network between the bilateral thalamic pulvinar region and the posterior cingulate /precuneus after the treatment of levothyroxine(the left:P =0.007,the right:P =0.001 ).Conclusion The resting-state functional connec-tivity strength between the bilateral thalamic and the posterior cingulate /precuneus are significantly lower after the treatment of the levothyroxine in patients with hypothyroidism.关键词
甲状腺功能减退症/甲状腺素/脑/磁共振成像Key words
Hypothyroidism/Thyroxine/Brain/Magnetic resonance imaging分类
医药卫生引用本文复制引用
曾宪忠,何晓松,王芬,朱敏,陈章祥,朱德发..左旋甲状腺素对甲状腺功能减退症患者脑默认网络静息态功能连接的影响[J].中国临床保健杂志,2017,20(1):14-16,3.基金项目
国家自然科学基金 （）
