药学研究2016，Vol.35Issue(12)：683-686,4.DOI:10.13506/j.cnki.jpr.2016.12.001
贝伐单抗激活 M2巨噬细胞促进肿瘤转移
Bevacizumab promotes cancer metastasis by activating M2 macrophage
摘要
Abstract
Objective To study the relationship between bevacizumab,macrophages,and tumor cells in the tumor mi-croenvironment,and find the potential mechanism of invalid treatment of bevacizumab in HCC(hepatic cell carcinoma). Methods The phenotype of macrophages in HCC was determined by immunohistochemistry.M2 macrophages and tumor cells were cocultured and bevacizumab was added.The release of inflammatory cytokines and vascular growth factor were de-tected by ELISA.The impact of supernant from coculture system on tumor cell migration was detected.ResuIts Most macro-phages in HCC microenvironment had M2 characteristics.Bevacizumab increased the level of inflammatory cytokines and vascular endothelial growth factor(VEGF)significantly in the M2 macrophages and tumor cells coculture system.Supernant from M2 macrophages and tumor cells coculture system promoted tumor cell migration.ConcIusion Bevacizumab can acti-vate M2 macrophage and promote cancer metastasis.关键词
贝伐单抗/M2 型巨噬细胞/炎症因子/肿瘤转移Key words
Bevacizumab/M2 macrophage/Inflammatory cytokines/Tumor cell migration分类
医药卫生引用本文复制引用
王卓,刘怀莹..贝伐单抗激活 M2巨噬细胞促进肿瘤转移[J].药学研究,2016,35(12):683-686,4.基金项目
南京中医药大学哲学社会科学项目（No.13XZR19）；国家自然科学基金重大研究计划集成项目 （）
