水生生物学报2017，Vol.41Issue(1)：1-8,8.DOI:10.7541/2017.1
斑马鱼IRF11基因的鉴定、亚细胞定位及表达特征
IDENTIFICATION, SUBCELLULAR LOCALIZATION AND EXPRESSION CHARACTERIZATION OF ZEBRAFISH IRF11
摘要
Abstract
Previous studies have shown that IRF11 is a fish-specific gene. There is confusion in nomenclature of IRF1 and IRF11 in the version 9 of the zebrafish genome. Herein, gene synteny of IRF1 and IRF11 was analyzed in some vertebrates, suggesting that IRF11 and IRF1 are two different genes and are not appropriate to name IRF1b and IRF1a, respectively. Phylogenetic tree analysis showed that fish IRF11 shows similar evolution distance to either IRF1 or IRF2, and that fish IRF11 occurred earlier in a vertebrate ancestor than did fish IRF1 and IRF2 likely due to gene loss in nonfish vertebrates during evolution. Like vertebrate IRF1, zebrafish IRF11 resided in nucleus, which was suffi-ciently directed by a nuclear localization sequence in N-terminal DNA binding domain. Expression analysis revealed that zebrafish IRF11 was transcriptionally induced by poly (I:C), although at a lower level than zebrafish IRF1.关键词
斑马鱼/IRF11/亚细胞定位/表达Key words
Zebrafish/IRF11/Subcellular localization/Inducible expression分类
生物科学引用本文复制引用
熊亚玮,张义兵,桂建芳..斑马鱼IRF11基因的鉴定、亚细胞定位及表达特征[J].水生生物学报,2017,41(1):1-8,8.基金项目
国家自然科学基金(31272690、31572646)资助[Supported by the National Natural Science Foundation of China (31272690,31572646) （31272690、31572646）
