陕西医学杂志2017，Vol.46Issue(1)：5-6,21,3.DOI:10.3969/j.issn.1000-7377.2017.01.002
钙拮抗剂对大鼠脑缺血后血脑屏障通透性的影响
Effect of calcium antagonist on the permeability of blood brain barrier (BBB) after cerebral ischemia in rats
宋江莉 1袁婕2
作者信息
- 1. 陕西省人民医院神经内一科 西安 710068
- 2. 陕西省富平县医院内二科 富平 711700
- 折叠
摘要
Abstract
Objective :To observe the effect of calcium antagonist on the permeability of blood brain barrier (BBB) after cerebral ischemia in rats .Methods :150 rat models of cerebral ischemia‐reperfusion (CIR) were pre‐pared and the brains of subjects were reperfusion after ischemia in 2h .The rats were divided into observation group (nimodipine) and control group (normal saline) ,respectively to reperfusion in 6h ,12h ,24h ,48h ,72h time points , to observe the BBB permeability damage and Measurement infarct volume percentage on each time point .Results :with the prolongation of time ,the percentage of BBB permeability and infarct volume increased gradually after CIR , and reached the peak in 12h and 48h .The BBB permeability and the percentage of infarct volume in the observation group were significantly higher than those in the control group (P< 0 .05) .Conclusion :CIR can increase the per‐meability of BBB ,increase the percentage of infarct volume ,and the early use of calcium antagonists can aggravate the situation .关键词
脑缺血/病理生理学/钙通道阻滞药/治疗应用/血脑屏障/尼莫地平Key words
Brain ischemia/pathology/Calcium channel blockers /therapeutic use/Blood-brain barrier/Nimodipine分类
医药卫生引用本文复制引用
宋江莉,袁婕..钙拮抗剂对大鼠脑缺血后血脑屏障通透性的影响[J].陕西医学杂志,2017,46(1):5-6,21,3.
