陕西医学杂志2017，Vol.46Issue(1)：22-24,3.DOI:10.3969/j.issn.1000-7377.2017.01.009
激素对难治性支原体肺炎患儿肺泡灌洗液细胞因子的影响
Hormone refractory mycoplasma pneumonia lavage cytokines
摘要
Abstract
Objective :To explore the impact of hormone refractory mycoplasma pneumonia lavage cytokines . Methods :35 cases of children with bronchial foreign bodies not associated with infection in the control group ,90 pa‐tients were randomly divided into non‐hormonal group (45 cases) and the hormone group (45 cases) .Non‐hormonal symptomatic treatment group ,no hormone treatment ,observation group were intravenous methylprednisolone treat‐ment program ,observed the effect of hormone therapy group and the group of non‐hormonal ,cooling time ;observa‐tion group with methylprednisolone for 3 days ,all soft underwent bronchoscopy and lavage ,bronchoalveolar lavage fluid was observed in IFN ‐γ ,TNF ‐α ,IL 1β ,IL‐α ,IL‐2 ,IL‐ 4 ,IL‐6 ,IL‐8 ,IL‐10 ,IL‐12 .Results :Children with fe‐ver time hormone group ,cough disappeared significantly shorter than non‐hormonal group (P< 0 .05) ;3 days after treatment ,the hormone group had fever in 16 patients (35% ) ,None of fever in children with body temperature re‐turned to normal ,rather than the hormone group with conventional medication ;hormone group ,the total effective rate of 90 .5% was significantly higher than 79 .8% (P< 0 .05) ;after treatment ,the hormone group and hormone group lavage cytokines was not statistically significant comparison (P > 0 .05) ;the two groups and the control group ,the cytokines were significantly higher (P< 0 05) ;fever group compared to the non‐fever group of cytokines IFN‐γ ,TNF‐ α ,IL‐1β ,IL‐2 ,IL‐4 ,IL‐6 ,IL‐8 ,IL‐10 ,IL‐12 were decreased ,fever group wherein IL‐2 and IL‐8 was significantly lower than fever group (P< 0 .05) .Conclusion :The use of hormone therapy for refractory myco‐plasma pneumonia in children can bronchoalveolar lavage fluid IL‐l β ,IL‐4 ,IL‐6 ,IL‐8 ,IL‐10‐ increased ,while in a short time so that children in the fever .关键词
肺炎 ,支原体/药物疗法/甲泼尼龙/治疗应用/细胞因子类/代谢Key words
Pneumonia ,mycoplasma/drug therapy/Methylprednisolone/therapeutic use/Cytokines/me-tabolism分类
医药卫生引用本文复制引用
冀超玉,牟荣芳..激素对难治性支原体肺炎患儿肺泡灌洗液细胞因子的影响[J].陕西医学杂志,2017,46(1):22-24,3.基金项目
河北省衡水市科技计划项目 （）
