天津科技大学学报2016，Vol.31Issue(6)：17-20,4.DOI:10.13364/j.issn.1672-6510.20160078
α-芳基磺酰基取代的丙基异腈的合成
Synthesis ofα-Aryl Sulfonyl Substituted Propylisocyanide
摘要
Abstract
Isocyanide is an important intermediate in organic synthesis,which can participate in many reactions.Among those,tosylmethyl isocyanide(TosMIC)was widely used in the synthesis of heterocycles.Sulfonyl substituted alkylisocya-nide is a novel TosMIC analogue.Previous researches showed thatα-tosylmethyl substituted alkylisocyanide,which was synthesized by alkylation of TosMIC,was used in the synthesis of poly-substituted heterocycles.However,otherα-aryl sul-fonyl substituted alkylisocyanide could not be prepared with this method.In this research,we synthesized fourα-aryl sul-fonyl substituted propylisocyanide from substituted benzenesulfonyl chloride through hydrolysis,acidification,Mannich and dehydration reaction.The structure of the new synthesized compounds was confirmed by IR,1H NMR,13C NMR and high resolution mass spectrum(HRMS).关键词
磺酰基/丙基异腈/合成Key words
sulfonyl/propylisocyanide/synthesis分类
医药卫生引用本文复制引用
丁芳,秦龙,盛亚茹,芦逵..α-芳基磺酰基取代的丙基异腈的合成[J].天津科技大学学报,2016,31(6):17-20,4.基金项目
国家自然科学基金资助项目(21202118) （21202118）
