现代医药卫生2017，Vol.33Issue(1)：27-29,3.DOI:10.3969/j.issn.1009-5519.2017.01.011
脱甲氧基姜黄素纳米脂质载体冻干工艺的优化
Optimization of freeze-drying technology of demethoxy curcumin nanostructured lipid carriers
摘要
Abstract
Objective To optimize the freeze-drying technology of demethoxy curcumin nanostructured lipid carriers. Methods With the appearance,color and redispersibility as the investigation indexes,the influence of types and concentrations of cryoprotectant on nanostructured lipid carriers freeze-dried powder was investigated and the parameters of freeze-drying tech-nology was optimized. Results The optimized freeze-drying technology was as follows:adding 5%mannitol as a cryoprotectant into nanostructured lipid carriers emulsion,prefreezing at-80℃for 24 h after shaking,heating up to-35℃,maintaining for 16 h, then heating up to 30℃and maintaining for 8 h. Conclusion The freeze-dried powder obtained by adopting optimized technology is loose and easy to be dispersed,which improves the stability of preparation.关键词
姜黄素/冷冻干燥法/冻干工艺/纳米脂质载体Key words
Curcumin/Freeze drying/Freeze drying process/Nanostructured lipid carriers引用本文复制引用
代文婷,陈进,何争民,王凤玲,陈卫东..脱甲氧基姜黄素纳米脂质载体冻干工艺的优化[J].现代医药卫生,2017,33(1):27-29,3.基金项目
合肥市第二人民医院院级青年基金项目（院科教[2014]69号）。 （）
