中国病理生理杂志2017，Vol.33Issue(1)：184-188,5.DOI:10.3969/j.issn.1000-4718.2017.01.032
胃肠道Cajal间质细胞起搏功能的研究进展
Research progress on pacemaker function of interstitial cells of Cajal in gastrointestinal tract
摘要
Abstract
[ ABSTRACT] Interstitial cells of Cajal ( ICC) is the pacemaker in the gastrointestinal tract , which is closely as-sociated with the formation of slow wave and the regulation of gastrointestinal motility .As the pacemaker of gastrointestinal tract, the activation of pacing signal is triggered by the local calcium oscillation in the ICC .The change of calcium concen-tration can activate many relevant ion channels , such as NSCC, ANO1, VGCC, HCN channels and potassium channels , which can generate a large number of pacing current to form the slow wave and then propagated by the gap junction between the ICC networks and smooth muscle cells to make the peristalsis of gastrointestinal tract in autonomic rhythm .However, the mechanism of these ion channels in the pacemaker activity is still unclear , so we refer to make a review about the re-search progress on these pacemaker channels in this article to illuminate the mechanism of pacemaker activity in ICC .关键词
Cajal间质细胞/起搏机制/离子通道Key words
Interstitial cells of Cajal/Pacemaking mechanism/Ion channel分类
医药卫生引用本文复制引用
陈健海,仲婕,王凡,孔桂美,董小耘,朱海航,卜平..胃肠道Cajal间质细胞起搏功能的研究进展[J].中国病理生理杂志,2017,33(1):184-188,5.基金项目
国家自然科学基金资助项目（No．81673736）；江苏省普通高校研究生实践创新计划 （）
