中国药房2017，Vol.28Issue(1)：27-30,4.DOI:10.6039/j.issn.1001-0408.2017.01.07
黄柏不同炮制品对甲亢型肾阴虚模型大鼠甲状腺和肾上腺皮质功能的影响
Effects of Different Processed Products of Phellodendron chinense on Thyroid Gland and Adrenocortical Function of Kidney-Yin Deficiency Model Rats with Hyperthyroidism
摘要
Abstract
OBJECTIVE:To compare effects of Phellodendron chinense,stir-baked P. chinense with yellow rice wine and stir-baked P. chinense with salt solution on thyroid gland and adrenocortical function of kidney-Yin deficiency model rats with hyper-thyroidism. METHODS:88 rats were randomly divided into blank group,model group,yellow rice wine group,salt solution group,positive group(Liuwei dihuang pills,0.2 g/kg,calculated by crude drug),high-dose and low-dose groups of P. chinense, stir-baked P. chinense with yellow rice wine and stir-baked P. chinense with salt solution (9.519,1.058 g/kg,calculated by crude drug). Except for blank group,other groups were given levothyroxine sodium to induce kidney-Yin deficiency model;during mod-eling,treatment groups were given relevant medicine intragastrically,and other groups were given constant volume of solution in-tragastrically,once a day,for consecutive 3 weeks. After last administration,body weight,24 h urine amount,viscera(thymus, spleen) indexes were determined;the serum levels of free triiodothyronine (FT3),free thyroxine (FT4),vasopressin (AVP), cAMP and cGMP were determined as well as urine levels of 17-hydroxy steroid(17-OHCS). cAMP/cGMP ratio was also calculat-ed. RESULTS:Compared with blank group,body weight,24 h urine amount and viscera (thymus,spleen) indexes were de-creased significantly in model group;serum levels of FT3,FT4,AVP and cAMP,cAMP/cGMP ratio and urine level of 17-OHCS were increased significantly,while serum level of cGMP was decreased significantly,with statistical significance (P<0.01). Ex-cept for the body weight in stir-baked P. chinense with yellow rice wine group and the serum level of cGMP in high-dose and low-dose of stir-baked P. chinense with yellow rice wine group,above indexes of positive group,high-dose and low-dose groups of P. chinense,stir-baked P. chinense with yellow rice wine and stir-baked P. chinense with salt solution were all improved significantly(P<0.05 or P<0.01). The improvement degree order was as follows as stir-baked P. chinense with salt solu-tion>P. chinense>stir-baked P. chinense with yellow rice wine. Serum level of cAMP and cAMP/cGMP ratio in stir-baked P. chi-nense with salt solution high-dose group and serum levels of 17-OHCS in stir-baked P. chinense with salt solution high-dose and low-dose groups were significantly lower than in same dose group of P. chinense. CONCLUSIONS:P. chinense can improve thy-roid gland and adrenocortical function of kidney-Yin deficiency model rats with hyperthyroidism ,which can be enhanced by stir-baked with salt solution but attenuated by stir-baked with yellow rice wine. It indicates that Yin-nourishing effect of P. Chinese have been enhanced after stir-baked with salt.关键词
生黄柏/酒黄柏/盐黄柏/甲亢/肾阴虚模型/大鼠/滋阴Key words
Phellodendron chinense/Stir-baked Phellodendron chinense with yellow rice wine/Stir-baked Phellodendron chi-nense with salt solution/Hyperthyroidism/Kidney-Yin deficiency model/Rat/Yin-nourishing分类
医药卫生引用本文复制引用
张凡,徐珊,刘蓬蓬,贾天柱..黄柏不同炮制品对甲亢型肾阴虚模型大鼠甲状腺和肾上腺皮质功能的影响[J].中国药房,2017,28(1):27-30,4.基金项目
国家自然科学基金资助项目(No.81274083) （No.81274083）
2015年公益性科研专项项目(No.201507002) （No.201507002）
