中国药房2017，Vol.28Issue(1)：103-106,4.DOI:10.6039/j.issn.1001-0408.2017.01.27
Box-Behnken响应面法优化大蒜油提取工艺
Optimization of the Extraction Technology of Garlic Oil by Box-Behnken Response Surface Method
摘要
Abstract
OBJECTIVE:To optimize the extraction technology of garlic oil. METHODS:Using extraction rate of garlic oil as index,based on single factor test,Box-Behnken response surface method was used to optimize conditions of steam distillation method for the extraction of garlic as fermentation time,solid to liquid ratio,fermentation temperature and the verification test were made for the optimized technology. RESULTS:The optimal extraction technology was as follows as fermentation time of 4.5 h,solid to liquid ratio of 1:7,fermentation temperature of 55 ℃. The average extraction rate of garlic oil in verification test was 0.32%(RSD=1.43%,n=3);the relative error between the measured value and predicted value was 0.06%. CONCLUSIONS:Box-Behnken response surface method is simple,reasonable and feasible to optimize the extraction technology of garlic oil,which can provide a scientific basis for industrial production.关键词
大蒜油/水蒸气蒸馏法/Box-Behnken响应面法/提取工艺/优化Key words
Garlic oil/Steam distillation/Box-Behnken response surface method/Extraction technology/Optimization分类
医药卫生引用本文复制引用
康冰亚,刘瑞新,桂新景,段晓颖,李学林,徐立然..Box-Behnken响应面法优化大蒜油提取工艺[J].中国药房,2017,28(1):103-106,4.基金项目
国家中医药管理局国家中医药临床研究基地业务建设科研专项课题(No.JDZX2015162) （No.JDZX2015162）
郑州市科技局项目(No.CZSYJJ-14012) （No.CZSYJJ-14012）
