中国药房2017，Vol.28Issue(1)：107-110,4.DOI:10.6039/j.issn.1001-0408.2017.01.28
黄芩苷单层渗透泵片的制备工艺及体外释药行为研究
Study on Preparation Technology and in vitro Drug Release Behavior of Baicalin Monolithic Osmotic Pump Tablets
摘要
Abstract
OBJECTIVE:To prepare Baicalin monolithic osmotic pump tablets and investigate its in vitro drug release behavior. METHODS:Using accumulative release rate as evaluation index,baicalin solid dispersion was prepared to improve solubility,sin-gle factor test and orthogonal test were used to optimize preparation technology(the amount of penetrating agent and pore-forming agent,weight gaining of coating film) of monolithic osmotic pump tablets using baicalin solid dispersion as intermediate. Release rate and mechanism of samples prepared by optimized technology were investigated in 3 kinds of release medium (water,0.1 mol/L HCl,simulated gastric fluid). RESULTS:The optimal preparation technology was that penetrating agent sodium chloride was 30 mg;pore-forming agent polyethylene glycol 400 was 20% amount of excipient cellulose acetate;weight gaining of coating film was 2%. RSD of 12 h accumulative release rate was 1.06%(n=3)for 3 batches of Baicalin monolithic osmotic pump tablets pre-pared by optimized technology. 12 h accumulative release rate of them in 3 kinds of medium were similar to each other,being all more than 80%. Release equation was in line with zero-order drug release model (r=0.9985). CONCLUSIONS:Prepared Ba-icalin monolithic osmotic pump tablets after optimization can release drug at controlled rate.关键词
关健词黄芩苷单层渗透泵片/固体分散体/制备工艺/正交试验/体外释药Key words
Baicalin monolithic osmotic pump tablets/Solid dispersion/Preparation technology/Orthogonal test/in vitro drug release分类
医药卫生引用本文复制引用
王汝兴,于海龙,薛禾菲,刘喜纲,刘翠哲..黄芩苷单层渗透泵片的制备工艺及体外释药行为研究[J].中国药房,2017,28(1):107-110,4.基金项目
河北省高等学校科学研究计划(No.ZH2012050) （No.ZH2012050）
河北省高等学校科学技术研究项目(No.QN2014145) （No.QN2014145）
