中国药房2017，Vol.28Issue(1)：115-118,4.DOI:10.6039/j.issn.1001-0408.2017.01.30
沙棘总黄酮-聚乙烯吡咯烷酮K30固体分散体的制备、表征及体外溶出研究
Preparation,Characterization and in vitro Dissolution Study of Total Flavonoids of Hippophae rhamnoi-des-PVP K30 Solid Dispersion
田茜 1何晨 1贺敬霞 1尹蓉莉 1杨军宣 2张礼1
作者信息
- 1. 成都中医药大学药学院,成都 611137
- 2. 重庆医科大学中医药学院,重庆 400016
- 折叠
摘要
Abstract
OBJECTIVE:To prepare total flavonoids of Hippophae rhamnoides(TFH)-PVP K30 solid dispersion,and to char-acterize and study its in vitro dissolution. METHODS:Solvent method was used to prepare TFH-PVP K30 solid dispersion with dif-ferent drug-loading ratio of 1:1,1:2,1:3,1:4,1:5;single factor test was designed to screen drug-loading ratio using dissolution parameter Td as index;orthogonal test was designed to optimize ultrasonic time,temperature of water bath and drying time for prep-aration technology using in vitro dissolution rate as index,and then validated. SEM,DSC and FT-IR were used to characterize sol-id dispersion. RESULTS:Td of TFH-PVP K30 solid dispersion was the lowest when drug-loading ratio was 1:3. Optimal technolo-gy was ultrasonic time 10 min,temperature of water bath 60 ℃ and drying time 12 h. 90 min accumulative dissolution rate of pre-pared TFH-PVP K30 solid dispersion was 90.22% in average(RSD=1.74%,n=3). The results of SEM,DSC and FT-IR showed that the drug as amorphous form dispersed in the PVP K30,the formation of hydrogen bond of the both. CONCLUSIONS:TFH-PVP K30 solid dispersion is prepared successfully,and in vitro dissolution rate of it is improved significantly.关键词
沙棘总黄酮/聚乙烯吡咯烷酮K30/固体分散体/溶出度/正交试验/表征Key words
Total flavonoids of Hippophae rhamnoides/PVP K30/Solid dispersion/Dissolution rate/Orthogonal test/Charac-terization分类
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田茜,何晨,贺敬霞,尹蓉莉,杨军宣,张礼..沙棘总黄酮-聚乙烯吡咯烷酮K30固体分散体的制备、表征及体外溶出研究[J].中国药房,2017,28(1):115-118,4.
