中国医院用药评价与分析2016，Vol.16Issue(12)：1644-1645,1646,3.DOI:10.14009/j.issn.1672-2124.2016.12.023
非布司他与小剂量苯溴马隆治疗高尿酸血症的对比研究
Comparative Study on Febuxostat and Low Doses of Benzbromarone in Treatemt of Hyperuricaemia
车嘉韦 1奚啸风1
作者信息
- 1. 武警浙江总队嘉兴医院药剂科，浙江嘉兴 314000
- 折叠
摘要
Abstract
OBJECTIVE:To probe into the treatment effects of febuxostat and low doses of benzbromarone in treatemt of hyperuricaemia .METHODS:120 patients with hyperuricemia admitted into Jiaxing Hospital of Zhejiang Armed Police Corps were selected to be divided into observation group and control group via the random number table , with 60 cases in each . The observation group were given febuxostat 80 mg, once a day;and the control group were treated with benzbromarone 25 mg, once a day.Various indicators , efficacy and adverse drug reactions of two groups were observed .RESULTS:After treatment , the uric acid of observation group was significantly lower than that of control group , with statistically significant difference(P<0.05).There was no statistically significant difference between two groups in leukocyte , creatinine, ALT (P>0.05).The total effective rate in observation group was 96.67%(58/60), and in control group was 90.00%(54/60), with statistically significant difference (P<0.05).The incidence of adverse drug reactions in observation group was 6.67%(4/60), significantly lower than that of control group [15.00%(9/60)], with statistical significance (P <0.05). CONCLUSIONS:Compared with benzbromarone , the efficacy of febuxostat in treatment of hyperuricemia is definite , which can reduce the uric acid level with high safety .关键词
非布司他/苯溴马隆/高尿酸血症/疗效Key words
Febuxostat/Benzbromarone/Hyperuricaemia/Efficacy分类
医药卫生引用本文复制引用
车嘉韦,奚啸风..非布司他与小剂量苯溴马隆治疗高尿酸血症的对比研究[J].中国医院用药评价与分析,2016,16(12):1644-1645,1646,3.
