摘要
Abstract
OBJECTIVE:To study the effects of magnesium sulfate on bleeding volume and TLR 4 level in pregnant women with severe preeclampsia after cesarean section , and to pro into the significance .METHODS:100 patients with severe preeclampsia admitted into Xiangyang First People ’s Hospital Affiliated to Hubei University of Medicine from Sept .2013 to Sept .2015 were selected to be divided into observation group and control group via the random number table, with 50 cases in each.After cesarean section , the control group were treated with misoprostol , while the observation group additionally received magnesium sulfate based on the control group .The bleeding volume , changes of blood pressure and adverse drug reactions of two groups were recorder and compared .And the ELISA method was used to detect and compare the serum levels of TLR 4 in the serum of women with severe preeclampsia .RESULTS:After treatment, there was no significant difference in systolic blood pressure between before and after treatment in control group ( P>0.05 ) , but diastolic blood pressure was lower than before treatment , the difference was statistically significant ( P<0.05 ) .The systolic pressure and diastolic pressure of the observation group were lower than before treatment, and the systolic and diastolic blood pressure in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05).In control group, the amount of 0-2 h, the amount of 2-24 h and the total amount of bleeding after cesarean section were higher than those in observation group , the difference was statistically significant (P<0.05).After treatment, the TLR4 level of peripheral serum in control group was higher than that in observation group , the difference was statistically significant ( P <0.05 ) .After treatment , individual patients had nausea , vomit and slight fever , which could be relieved after general support treatment; and the other patients had no obvious adverse drug reactions .CONCLUSIONS: Magnesium sulfate can reduce severe preeclampsia maternal serum TLR4 expression to achieve the purpose of treatment of postpartum hemorrhage , and the effects are significant with few adverse drug reactions and high safety;it is worth promoting .关键词
硫酸镁/重度子痫前期/剖宫产术/出血量/TLR4Key words
Magnesium sulfate/Severe preeclampsia/Csarean section/Bleeding volume/TLR4分类
医药卫生
