中国医院用药评价与分析2016，Vol.16Issue(12)：1664-1666,3.DOI:10.14009/j.issn.1672-2124.2016.12.031
硫酸镁与硝苯地平联合治疗妊娠期高血压疾病的疗效及安全性
Efficacy and Safety of Magnesium Sulfate and Nifedipine in Treatment of Pregnancy Induced Hypertension
陈瑜 1肖劲花 2李小群 1钟明1
作者信息
- 1. 深圳市宝安区妇幼保健院药剂科，广东深圳 518101
- 2. 深圳市宝安区妇幼保健院产科，广东深圳 518101
- 折叠
摘要
Abstract
OBJECTIVE:To study the efficacy and safety of magnesium sulfate and nifedipine in treatment of pregnancy induced hypertension . METHODS: 100 patients with pregnancy induced hypertension admitted into Shenzhen City Maternal and Child Health Hospital of Bao ’an District from Jan.2013 to Jun.2015 were selected to be divided into observation group and control group via taking computer random grouping method , with 50 cases in each . The control group were treated with magnesium sulfate , while the observation group received magnesium sulfate and nifedipine .The treatment effects and incidence of adverse drug reactions of two groups were observed and compared . RESULTS:The incidence of pregnancy adverse outcomes in observation group was 10%( 5/50 ) , significantly lower than that of control group [26%(13/50)], with statistically significant difference (P<0.05).The Apgar 1 min score and Apgar 5 min score of observation group were respectively (7.89 ±1.25) scores and (8.45 ±1.69) scores, significantly higher than those of control group [(7.03 ±1.12) scores and (7.56 ±1.55) scores], with statistically significant difference ( P <0.05 ) .Compared with before treatment , the systolic blood pressure , diastolic blood pressure , 24 hour urinary protein of two groups after treatment were significantly decreased , and the observation group was better than the control group , with statistically significant difference ( P<0.05 ) .The incidence of adverse drug reactions in two groups was relatively low , and there was no statistically significant difference between two groups ( P>0.05 ) .CONCLUSINS:Magnesium sulfate and nifedipine in treatment of pregnancy induced hypertension have obvious effects of lowering blood pressure and can effectively improve the pregnancy outcomes with high security .关键词
妊娠期高血压疾病/硫酸镁/硝苯地平/安全性Key words
Pregnancy induced hypertension/Magnesium sulfate/Nifedipine/Safety分类
医药卫生引用本文复制引用
陈瑜,肖劲花,李小群,钟明..硫酸镁与硝苯地平联合治疗妊娠期高血压疾病的疗效及安全性[J].中国医院用药评价与分析,2016,16(12):1664-1666,3.
