中国中医药信息杂志2017，Vol.24Issue(2)：21-24,4.DOI:10.3969/j.issn.1005-5304.2017.02.007
黄葵胶囊对糖尿病肾病血液透析患者微炎症和氧化应激状态的影响
Effects of Huangkui Capsules on Oxidative Stress and Micro-inflammation State in Diabetic ;Nephropathy Patients with Maintenance Hemodialysis
摘要
Abstract
Objective To investigate the effects of Huangkui Capsules on oxidative stress and micro-inflammation state in diabetic nephropathy patients with maintenance hemodialysis. Methods Forty-six patients with diabetic nephropathy who had received maintenance hemodialysis for over six month in Gansu Provincial People's Hospital were randomly divided into observation group (23 cases) and treatment group (23 cases) from January to December in 2014. Twenty healthy subjects who had physical examinations were selected as the control group at the same time. Observation group were given conventional hemodialysis for 4 hours, 3 times a week; treatment group were given conventional hemodialysis combined with Huangkui Capsules, orally, 2.5 g each time, 3 times a day. Both groups were treated for 8 weeks. Blood was collected before and after treatment for detection of hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), white blood cell (WBC), malondialdehyde (MDA), cycle of advanced oxidation protein products (AOPP), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels. Results The levels of IL-6, TNF-α, AOPP, WBC, MDA and hs-CRP were significantly higher in the observation group and the treatment group compared with the control group before treatment (P<0.01), SOD and GSH-Px levels decreased (P<0.01); there was no statistical significance between the observation group and the treatment group (P>0.05). After treatment, the levels of IL-6, hs-CRP, MDA and AOPP increased in the observation group (P<0.05), GSH-Px and SOD decreased (P<0.05), there were no statistical significance in TNF-αand WBC (P>0.05);The levels of AOPP, TNF-α, hs-CRP, WBC, MDA and IL-6 in treatment group significantly decreased (P<0.01), GSH-Px and SOD significantly increased (P<0.01); there was statistical significance between the observation group and the treatment group (P<0.01). Conclusion Micro-inflammation state and oxidative stress exist generally in diabetic nephropathy maintenance hemodialysis patients. Huangkui Capsules can improve oxidative stress and micro-inflammation state in diabetic nephropathy maintenance hemodialysis patients.关键词
黄葵胶囊/糖尿病肾病/维持性血液透析/微炎症/氧化应激Key words
Huangkui Capsules/diabetic nephropathy/maintenance hemodialysis/micro-inflammation/oxidative stress分类
医药卫生引用本文复制引用
赵金香,李耀华,谢萍..黄葵胶囊对糖尿病肾病血液透析患者微炎症和氧化应激状态的影响[J].中国中医药信息杂志,2017,24(2):21-24,4.基金项目
甘肃省卫生行业科研计划项目 （）
