中国中医药信息杂志2017，Vol.24Issue(2)：70-75,6.DOI:10.3969/j.issn.1005-5304.2017.02.018
活血止痛纳米凝胶贴膏经皮渗透特性及药效评价
Evaluation on Transdermal Absorption Properties and Efficacy of Huoxue Zhitong ;Cataplasm
摘要
Abstract
Objective To study the effects of microemulsion/ethosomes on transdermal absorption properties and efficacy of Huoxue Zhitong Cataplasm. Methods The improved Franz diffusion cells were used for the in-vitro permeation experiment with rat skins as the barriers, which was used to evaluate the transdermal absorption properties. In the erxeriment, the contents of paeonol, eugenol and methyl salicylate were used as markers, and detected by ultra performance liquid chromatography to evaluate the transdermal absorption effects. The anti-inflammatory and analgesia activity were evaluated through the writhing plate experiments. Results The cumulative release rate of paeonol in Huoxue Zhitong Cataplasm, Microemulsion Huoxue Zhitong Cataplasm and Ethosomes Huoxue Zhitong Cataplasm were, in order, 65.30%, 61.30%and 60.20%in 24 h;eugenol were, in order, 51.08%, 54.71% and 55.66% in 24 h; methyl salicylate were, in order, 49.20%, 65.17% and 72.15% in 24 h. Furthermore, Microemulsion Huoxue Zhitong Cataplasm high-dose group and Ethosomes Huoxue Zhitong Cataplasm medium-dose group had good effects on reducing the inflammatory exudate of peritoneal capillary and capillary permeability (P<0.05) in animal models. Conclusion Huoxue Zhitong Cataplasm based on microemulsion/ethosomesnano-technology has good transdermal absorption properties and efficacy.关键词
活血止痛凝胶贴膏/微乳/醇质体/透皮试验/抗炎/镇痛Key words
Huoxue Zhitong Cataplasm/microemulsion/ethosomes/transdermal experiment/anti-inflammatory/analgesia activity分类
医药卫生引用本文复制引用
姚瑶,冯伟红,王岚,易红,梁日欣,何爱萍,殷晓杰,杜茂波,刘淑芝..活血止痛纳米凝胶贴膏经皮渗透特性及药效评价[J].中国中医药信息杂志,2017,24(2):70-75,6.基金项目
国家科技重大专项-重大新药创制 （）
