中国中医药信息杂志2017，Vol.24Issue(2)：91-93,3.DOI:10.3969/j.issn.1005-5304.2017.02.023
β-榄香烯纳米聚合物胶束包封率、载药量及释药性测定
Determination of Encapsulation Efficiency and Medicine Loading and Release ofβ-elemene inβ-elemene-loaded Nano Polymeric Micelles
摘要
Abstract
Objective To establish a RP-HPLC method for the determination of encapsulation efficiency (EE) and medicine loading (ML) in β-elemene-loaded Nano Polymeric Micelles; To study its release characteristic in vitro. Methods DSPE-PEG2000 was used as carrier to prepare medicine-loaded micelles. EE and ML were determined by petroleum ether extraction method, and its release characteristic in vitro was studied by dialysis method. Results The average EE and ML ofβ-elemene-loaded Nano Polymeric Micelles were 89.47%and 8.33%, respectively. Its release characteristic was slow. Conclusion The method for EE and ML determination is simple and accurate, and the prepared micelles have the property of sustained release.关键词
β-榄香烯纳米聚合物胶束/包封率/载药量/释药性Key words
β-elemene-loaded Nano Polymeric Micelles/encapsulation efficiency/medicine loading/release characteristic分类
医药卫生引用本文复制引用
王静,李学涛,袁子民..β-榄香烯纳米聚合物胶束包封率、载药量及释药性测定[J].中国中医药信息杂志,2017,24(2):91-93,3.基金项目
辽宁省科学技术计划 （）
