中华耳科学杂志2016，Vol.14Issue(6)：837-840,4.DOI:10.3969/j.issn.1672-2922.2016.06.026
光遗传学技术在听觉研究中的应用
Applications of optogenentics in auditory research
摘要
Abstract
Optogenentics involves genetic coding, features a single-component approach and can modulate selected cells in complex tissues. It has made a profound impact on neuroscience research. As opsins continue to be optimized and di-versified, application of optogenetic tools has been attempted in every field of life science to different organism models. Sound signals are transduced via hair cells in the cochlea, encoded as electric signals by spiral ganglion neurons (SGNs), and eventually transmitted to the auditory center. In individuals with deafness, hearing can be partially restored by electric stimulation of SGNs, although sometimes with poor temporal and intensity resolution. Optical stimulation can be selectively focused, which may greatly improve the resolution of sound coding compared to electric stimulation. This paper reviews ap-plications of optogenentic technology in auditory research and its potentials in future scientific research and clinical utilities.关键词
光遗传学/螺旋神经节/听觉系统Key words
optogenentics/Hearing system/spiral ganglion neurons分类
医药卫生引用本文复制引用
刘晨,于宁..光遗传学技术在听觉研究中的应用[J].中华耳科学杂志,2016,14(6):837-840,4.基金项目
本文由国家973计划重大科学研究计划干细胞项目（2012CB967900与2014CB943002）、军队项目（BWS14B080、JDZYY20132）、国家自然基金项目（81271081、81528005与81470700）及北京市项目（PXM2014-178304-000002-00130228）共同支持下在解放军总医院完成。This work was supported by grants from the National Basic Research Program of China (973 Program)(#2012CB967900 and 2014CB943002), PLA Medical Technology key project of scientific research（BWS14B080、JDZYY20132），the National Natural Science Foundation of China (NSFC #81271081、81528005 and 81470700)， Beijing Municipal Science and Technology Project （973 Program）
