北京师范大学学报（自然科学版）2016，Vol.52Issue(6)：681-686,6.DOI:10.16360/j.cnki.jbnuns.2016.06.004
单线态氧分子：生物学和医学
Singlet oxygen:biology and medicine
摘要
Abstract
The delta singlet oxygen (1 O2 ) is a highly reactive messenger molecule generated in a number of physiological processes.1 O2 initiates oxidation around the double bond in defined reactions,with the major target being structural and functional proteins.Singlet oxygen typically activates and transfixes the CCK receptor in the active state, with differential modulation of other G protein-coupled receptors.Singlet oxygen mainly exerts inhibitory effects on the voltage-gated sodium (Nav )and potassium channels (Kv ),but activates TRPA1 and TRPV1 .1 O2 probably helps to propagate oxidatively-activated autoactive CaMKII.Photopharmacology based on the photodynamic generation of singlet oxygen has emerged to study the photodynamic modulation of cellular signaling and cellular physiology,besides the already established photodynamic therapy of cancer and other non-malignant lesions.关键词
单线态氧分子/光动力作用/胆囊收缩素1型受体/离子通道/光控药理学Key words
singlet oxygen/photodynamic action/CCK1 receptor/ionic channel/photopharmacology (optopharmacology)分类
生物科学引用本文复制引用
崔宗杰..单线态氧分子：生物学和医学[J].北京师范大学学报（自然科学版）,2016,52(6):681-686,6.基金项目
Supported by The National Natural Science Foundation of China (31670856,31270892)and The National Basic Research Program (973 Program),of The Ministry of Science and Technology of China (2011CB809101) （31670856,31270892）
