北京师范大学学报（自然科学版）2016，Vol.52Issue(6)：800-808,9.DOI:10.16360/j.cnki.jbnuns.2016.06.018
STIM、Orai及其介导的钙池操纵钙内流∗
Stores-operated calcium entry and mediator proteins STIM,Orai:a brief review
摘要
Abstract
STIM/Orai-mediated stores-operated calcium entry (SOCE)is an important Ca2+ influx pathway in multiple cell types. SOCE participates in numerous cellular processes such as the regulation of gene expression,cell proliferation,organ development,and immune responses.In the present paper we review the discovery of SOCE and the identification of STIM and Orai proteins via RNAi and high throughput screening technologies.With a focus on STIM,we also discuss some recent findings about STIM,Orai and their coupling, in the hope to provide some hints towards the detailed mechanisms underlying STIM-Orai interaction.关键词
钙池操纵钙内流/STIM/OraiKey words
SOCE/STIM/Orai分类
生物科学引用本文复制引用
刘金豆,郑思思,王友军..STIM、Orai及其介导的钙池操纵钙内流∗[J].北京师范大学学报（自然科学版）,2016,52(6):800-808,9.基金项目
国家自然科学基金资助项目(31471279) （31471279）
