川北医学院学报2016，Vol.31Issue(6)：813-815,3.DOI:10.3969/j.issn.1005-3697.2016.06.009
转化生长因子β1和细胞外信号调节激酶1／2在冠心病猝死早期心肌缺血中的表达及意义
Expression and significance of TGF-β1 and ERK1/2 in the sudden death of coronary heart disease early myocardial ischemia
摘要
Abstract
Objective:To observe the expressions of transforming growth factor-β1 (TGF-β1 )and extracellular signal-regulated kinase 1/2 (ERK1/2)in the myocardium of patients of sudden coronary death and to explore the significance of SCD diagnosis.Meth-ods:The heart samples of thirty cases of sudden coronary death were chosen as experiment group while the heart samples of fifteen cases of non sudden coronary death were chosen as control group.Immunohistochemical staining was employed to examine the expressions of TGF-β1 and ERK1/2 in the myocardium.Results:The expressions of TGF-β1 and ERK1/2 in experiment group was significantly high-er than those in control group,the t value of TGF-β1 was 19.807,ERK1/2 was 15.478,two indicators between two groups were com-pared,the differences were statistically significant (P <0.01 ).The expressions of TGF-β1 positively related to ERK1/2 in SCD (r=0.64,P<0.01).Conclusion:TGF-β1/ERK1/2 signaling pathway could participate in the process of apoptosis,the detection of the positive expressions of two indicators in the myocardium may provide an objective index for the early pathological diagnosis of SCD.关键词
冠心病猝死/转化生长因子 β1/细胞外信号调节激酶 1/2/免疫组织化学Key words
Sudden coronary death/Transforming growth factor-β1/Extracellular signal-regulated kinase 1/2/Immunohistochemistry分类
医药卫生引用本文复制引用
章丽霞,王宇,张丽华,牛彩琴..转化生长因子β1和细胞外信号调节激酶1／2在冠心病猝死早期心肌缺血中的表达及意义[J].川北医学院学报,2016,31(6):813-815,3.基金项目
四川省教育厅课题 （）
