川北医学院学报2016，Vol.31Issue(6)：828-831,4.DOI:10.3969/j.issn.1005-3697.2016.06.013
同时性双侧原发性乳腺癌术后放疗临床分析
Clinical analysis of postoperative radiotherapy for synchronous bilateral primary breast cancer
摘要
Abstract
Objective:To retrospectively analyze the clinical efficacy and adverse reactions of postoperative radiotherapy for synchronous bilateral primary breast cancer (sBPBC).Methods:The data of 14 sBPBC patients were collected treated with postopera-tive radiotherapy among September 2006 to April 2015 in our hospital.Retrospectively analysis the clinical pathological features,obser-vation the 5 years local control rate (LCR),5 years disease progression free survival (PFS)and the 5 years overall survival rate (OS) and the adverse reactions of irradiation-induced adverse reactions of the skin,lung and heart etc.Results:Among 14 cases of sBPBC, Luminal A and TNBC types less presented and molecular types of the first cancer and the second cancer had good consistency (Kappa=0.457).No distant metastasis was observed in SBPBC patients upon diagnosis.6 and 10 stages Ⅰ-Ⅱ cases presented in the first cancer and the second cancer respectively,accounting for 42.86% and 71.43%.The difference was not statistically significant.All pa-tients received postoperative radiotherapy,with no grade IV reaction and only a few of the lungs and heart toxicities.Grade Ⅲ irradia-tion-induced reaction appeared only in the irradiated skin,accounting for less than 15% (4/28,14.29%).There were no significant difference between the acute and late radiation reactions of the bilateral lungs and skin.Regardless of whether the first cancer occurred in the left side and the left side of the chest or not,no difference in cardiac toxicity and clinical symptoms.A total of 4 cases (28.57%) of sBPBC patients presented local recurrence.The 5 years LCR was 81.5%,6 cases died,5 years OS 71.4%,PFS 57.1% and the me-dian survival period was 95 months.Conclusion:The active multimodality treatment should be given for sBPBC patients,and good local control and survival could be achieved.Postoperative radiation of sBPBC patients had minor toxicities of which the clinical application was safe and effective.In the future,the patients with unilateral breast cancer should be followed up closely to gain the early diagnosis and treatment of contralateral breast cancer.It would be possible to further improve the curative effect of BPBC patients.关键词
乳腺癌/同时性/双侧/术后放疗/预后Key words
Breast cancer/Synchronous/Bilateral/Postoperative radiotherapy/Prognosis分类
医药卫生引用本文复制引用
顾科,胡群超,冀胜军,刘政操,李颖,陈杰,吴锦昌..同时性双侧原发性乳腺癌术后放疗临床分析[J].川北医学院学报,2016,31(6):828-831,4.基金项目
苏州市肿瘤临床医学中心项目 （）
