川北医学院学报2016，Vol.31Issue(6)：881-884,4.DOI:10.3969/j.issn.1005-3697.2016.06.029
全身化疗联合局部放疗对广泛期小细胞肺癌患者生存期的影响
Influence of general chemotherapy combined with local radiotherapy in patients with extensive stage small cell lung cancer
舒忠琴 1茅卫东 1沈冬 1于波 1顾小伟 1夏林云1
作者信息
- 1. 东南大学医学院附属江阴医院肿瘤放疗科，江苏 江阴 214400
- 折叠
摘要
Abstract
Objective:To evaluate the influence of general chemotherapy combined with local radiotherapy in the treatment of patients with extensive stage small cell lung cancer (ES-SCLC).Methods:Retrospective analysis the clinical data of 46 patients with ES-SCLC,and their clinical characters and survival outcomes were compared according to whether they received local treatment for me-tastases,radiotherapy for primary nidi and prophylactic cranial irradiation (PCI).Results:The median survival time (MST)in patients with single and multiple local radiotherapy and those without local radiotherapy for metastases was 12.1 months,18.5 months and 9.5 months respectively.The MST in patients with local treatment in limited time and selective time and those without local radiotherapy for metastases was 10.7 months,15.8 months and 9.1 months respectively,and it was significant difference when compared with the overall survival (OS)(P<0.01).MST in patients with radiochemotherapy and single chemotherapy was 13.7 months and 8.7 months respec-tively.MST in patients with and without PCI was 18.4 months and 10.1 months respectively,and there was significant difference in the comparison with overall survival (OS)(P<0.01).Cox multivariate regression analysis showed that local treatment for metastases,ra-diotherapy for primary nidi and application of PCI were protective independent prognostic factors for patients with ES-SCLC (P<0. 01).Conclusion:On the basis of systemic chemotherapy,the local treatment of chemotherapy,primary radiotherapy and PCI can pro-long the survival of patients with ES-SCLC.关键词
广泛期小细胞肺癌/化疗/放疗/全脑预防性照射治疗/预后Key words
Extensive stage small cell lung cancer/Chemotherapy/Radiotherapy/Prophylactic cranial irra-diation/Prognosis分类
医药卫生引用本文复制引用
舒忠琴,茅卫东,沈冬,于波,顾小伟,夏林云..全身化疗联合局部放疗对广泛期小细胞肺癌患者生存期的影响[J].川北医学院学报,2016,31(6):881-884,4.
