摘要
Abstract
Objective:To explore the influence of low-dose estrogen-progesterone replacement therapy (EPRT)in the treatment of perimenopausal syndrome (PMS)and its impact on the hormone levels.Methods:Totally 103 cases of PMS were randomly divided into treatment group(n=52)and control group(n=51).Both groups were given symptomatic treatment.Based on this,the treatment group was given low-dose EPRT.Twenty-eight days were as a cycle,totally 3 cycles.The following indexes were respectively observed and compared,including clinical efficacy,levels of follicle-stimulating hormone (FSH),luteinizing hormone (LH)and estradiol (E2 ) as well as changes of Kupperman scores,endometrial thickness and uterine volume before and after treatment.The adverse reactions were also recorded.Results:The overall response rate (ORR)of treatment group was significantly higher than that of control group (92.31% vs.72.55%,P<0.01).After treatment,the levels of serum FSH and LH went down,while that of E2 up dramatically in both groups,but the decreased and increased degrees of treatment group were more significant (P<0.01).After treatment,Kupperman scores in two groups decreased,but the decreased degree of treatment group was more larger than that of control group (P<0.01 ). When compared with pretreatment,the endometrial thickness increased a little,and uterine volume shrank slightly,but the difference was not statistically significant(P>0.05).There was no statistical significance between two groups by comparison with the adverse re-actions (P>0.05).Conclusion:Low-dose EPRT can effectively ameliorate the hormone levels and clinical symptoms of patients with PMS,with promising efficacy and less adverse reactions.关键词
雌激素/孕激素/围绝经期综合征/替代疗法/低剂量Key words
Estrogen/Progesterone/Perimenopausal syndrome/Replacement therapy/Low-dose分类
医药卫生
