重庆医学2017，Vol.46Issue(1)：36-39,4.DOI:10.3969/j.issn.1671-8348.2017.01.006
姜黄素对脑缺血再灌注损伤大鼠PI3K／AKT／mTOR的影响
Effect of curcumin on PI3K/AKT/mTOR in rats with cerebral ischemia-reperfusion injury
摘要
Abstract
Objective To explore the effect and mechanism of curcumin on rat cerebral ischemia reperfusion injury.Methods The rat model of cerebral ischemia reperfusion injury was constructed by the suture-occluded method.The effects of curcumin on cerebral infarction range,cerebral water content,neurological symptoms,cerebral histopathological morphology and expressions of PI3K,AKT,p-AKT,m-TOR,MDA,CAT,GPX,SOD,Bcl-2,Bax,Caspase-3 and Cleavage-Caspase-3 were evaluated.Results Cur-cumin had the protective effect on cerebral ischemia reperfusion injury,could alleviate the neurological symptoms,decreased the cer-ebral tissue pathological morphological changes and cerebral water content,in addition,which could alleviate the expressions of MDA,Bax,Cleavage-Caspase-3,IL-6,MCP-1 and TNF-αand increased the expressions of PI3K,p-AKT,mTOR,Bcl-2,Caspase-3, CAT,GPX and SOD.Conclusion The curcumin pretreatment has the significantly protective effect on cerebral ischemia-reperfusion injury,which may be associated with activating PI3K/AKT/mTOR signal pathway,while suppressing inflammation,apoptosis and oxidative stress.关键词
姜黄素/脑缺血/再灌注损伤/炎症/凋亡/氧化应激/PI3K/AKT/mTORKey words
curcumin/brain ischemia/reperfusion injury/inflammation/apoptosis/oxidative stress/PI3K/AKT/mTOR分类
医药卫生引用本文复制引用
兰晶,潘敬芳..姜黄素对脑缺血再灌注损伤大鼠PI3K／AKT／mTOR的影响[J].重庆医学,2017,46(1):36-39,4.基金项目
湖北省宜昌市科技基金资助项目（A11301-05）。 （）
