重庆医学2017，Vol.46Issue(1)：84-89,93,7.DOI:10.3969/j.issn.1671-8348.2017.01.020
白细胞介素2联合顺铂治疗恶性胸腔积液有效性及安全性的Meta分析
Effectiveness and safety of interleukin-2 plus cisplatin for treating malignant pleural effusion:a meta analysis
摘要
Abstract
Objective To systematically evaluate the effectiveness and safety of interleukin-2 plus cisplatin for treating ma-lignant pleural effusion(MPE)to provide a basis for clinical treatment strategy.Methods CBM,CNKI,VIP,Wanfang,Pubmed, Embase,Cochrane library clinical trial registration database were systematically retrieved.The randomized controlled trial(RCT) quality assessment criteria of Cochrane collaboration network was adopted for including the study quality.The data were extracted by meta analysis.Results (1)Thirty-four RCT involving 2 037 MPE patients were included,the quality of included RCT was ordi-nary;(2)compared with simple cisplatin,the merged RR values and their 95%CI of meta-analysis for ORR,fever,were 1.45 (1.36-1.54),2.37 (1.53 -3.66),respectively,the differences between the two groups were statistically significant(P <0.05 ). The merged RR values and their 95%CI of meta-analysis for leukopenia,myelosuppression and thoracalgia were 0.81 (0.61 -1.07),0.83(0.62-1.11)and 1.04(0.84-1.29)respectively,the differences between two groups were not statistically significant (P >0.05).Conclusion This study indicates that IL-2 plus cisplatin can significantly improve the clinical curative effect in the pa-tients with MPE,but has the adverse reactions of fever,etc.and the quality of included RCT is general.关键词
白细胞介素2/顺铂/胸腔积液,恶性/Meta分析Key words
interleukin-2/cisplatin/pleural effusion,malignant/meta analysis分类
医药卫生引用本文复制引用
孙永苹,汪成琼,陈玲,李娜娜,姚新生,肖政..白细胞介素2联合顺铂治疗恶性胸腔积液有效性及安全性的Meta分析[J].重庆医学,2017,46(1):84-89,93,7.基金项目
遵义医学院博士启动基金（F-617）；贵州省哲学社会科学规划基金（14GZYB58）；贵州省第五批科技创新人才团队项目[黔科合（2012）4011]。 （）
