南方医科大学学报2017，Vol.37Issue(1)：18-23,6.DOI:10.3969/j.issn.1673-4254.2017.01.04
孕晚期地诺前列酮栓引产的临床疗效及安全性：多中心回顾性分析
Clinical efficacy and safety of controlled-release dinoprostone insert：a multicenter retrospective study
摘要
Abstract
Objective To analyze the effectiveness and safety of controlled-release dinoprostone insert for term labor induction in the Pearl River Delta of Guangdong province. Methods Twenty hospitals using controlled-release dinoprostone insert for term labor induction in the Pearl River Delta of Guangdong province were stratified into provincial hospitals and municipal hospitals, and three hospitals of each level were selected as research units. According to the inclusion and exclusion criteria, 1390 pregnant women receiving term labor induction using controlled-release dinoprostone insert were retrospectively analyzed to evaluate the the effectiveness and safety with another 957 pregnant women with induced abortion using oxytocin as the control group. Results Compared with the control group, the controlled-release dinoprostone insert group showed a significantly longer length of the latent phase of labor (4.06 ± 2.65 vs 3.20 ± 2.08 h, P=0.003, 95%CI [0.182, 0.920]) and shorter lengths of the active phase (1.73±1.32 vs 2.22±1.75 h, P=0.000, 95%CI [-0.795,-0.363]) and the second stage of labor (0.49±0.37 vs 0.54 ± 0.43 h, P=0.003, 95%CI [-0.137,-0.028]). No significant differences were found in the length of the first stage of labor, the vaginal delivery rate, adverse reactions, or fetal outcomes between the two groups. Conclusion Controlled-release dinoprostone insert is effective and safe for labor induction at term.关键词
地诺前列酮栓/缩宫素/孕晚期引产/安全性/有效性Key words
controlled-release dinoprostone insert/oxytocin/induction at term/efficiency/safety引用本文复制引用
李雪媛,张建平,王志坚,安胜利,郭跃文,许燕文,朱斌,邬雪雪,陈翊,王晓怡,陈敦金,陈慧..孕晚期地诺前列酮栓引产的临床疗效及安全性：多中心回顾性分析[J].南方医科大学学报,2017,37(1):18-23,6.基金项目
广东省高等教育“创新强校工程”专项资金 （）
