南方医科大学学报2017，Vol.37Issue(1)：44-48,5.DOI:10.3969/j.issn.1673-4254.2017.01.08
英夫利西单抗治疗的小肠克罗恩病患者不同肠段黏膜愈合情况分析
Mucosal healing in different intestinal segments in patients receiving infliximab treatment for small bowel Crohn's disease
摘要
Abstract
Objective To evaluate the mucosal healing in the terminal ileum, colon and small bowel in patients receiving infliximab treatment for small bowel Crohn's disease (SBCD). Methods The clinical data of 18 patients with SBCD treated with infliximab were analyzed for laboratory findings (routine blood tests, C-reative protein, and albumin), Crohn’s disease activity index (CDAI), Lewis score (LS), Crohn's disease simplified endoscopic score (SES-CD) and adverse effects before and after 30 weeks of infliximab treatment. Results SES-CD, LS, CDAI and CRP were all decreased significantly, but the body mass index and albumin were significantly increased in the 18 patients after 30 weeks of IFX treatment. Sixteen (88.9%) of the patients were in clinical remission, 10 (58.8%) showed terminal ileum and colonic mucosal healing, 4 (22.2%) showed small bowel mucosal healing, and 3 (17.6%) were in deep remission. The 4 patients with small bowel mucosal healing all showed terminal ileum and colon mucosal healing, and 6 patients with terminal ileum and colon mucosal healing did not show small bowel mucosal healing. Conclusion Infliximab treatment can effectively reduce inflammatory activity, induce and maintain clinical remission of SBCD and achieve mucosal healing; small bowel mucosal healing occurs later than terminal ileum and colonic mucosal healing, indicating the importance of small bowel mucosal healing in efficacy analysis of the treatment.关键词
小肠克罗恩病/英夫利西单抗/黏膜愈合Key words
small bowel Crohn's disease/infliximab/mucosal healing引用本文复制引用
朱振浩,邱琛,张明,陈昭,向城,王新颖..英夫利西单抗治疗的小肠克罗恩病患者不同肠段黏膜愈合情况分析[J].南方医科大学学报,2017,37(1):44-48,5.基金项目
国家自然科学基金（H1609）Supported by National Natural Science Foundation of China (H1609) （H1609）
