南方医科大学学报2017，Vol.37Issue(1)：97-101,5.DOI:10.3969/j.issn.1673-4254.2017.01.18
重复经颅磁刺激对老年抑郁症患者临床症状及自杀意念的疗效
Efficacy of repetitive transcranial magnetic stimulation for alleviating clinical symptoms and suicidal ideation in elderly depressive patients:a randomized controlled trial
摘要
Abstract
Objective To assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) for alleviating the clinical symptoms and suicidal ideation in elderly patients with depression. Methods A total of 178 elderly depressive patients with suicidal ideation were randomized into rTMS treatment group (n=80) and control group (n=98) and treated with rTMS or sham rTMS treatment for 4 weeks in addition to conventional therapy with medications. The 24-item Hamilton Depression Scales (HAMD) and Self-rating Idea of Suicide Scale (SIOSS) were used to assess the severity of depression and the risk of suicide at the baseline and after 2 and 4 weeks of treatment. The treatment response was defined as a 25%reduction in HAMD scores from baseline, and an early improvement as 20% reduction in HAMD scores after 2 weeks of treatment. Results The two groups of patients were comparable for baseline socio-demographic characteristics and baseline SIOSS and HAMD scores (P>0.05). After 2 and 4 weeks of treatment, both SIOSS and HAMD scores were improved in the two groups, but the patients in rTMS group showed a significantly faster score reduction. A significantly higher rate of early improvement at 2 weeks (52.5%vs 28.6%;χ2=10.569, P<0.01) and a higher response rate at 4 weeks (77.5%vs 53.1%;χ2=15.470, P<0.05) were observed in rTMS group. Conclusions rTMS combined with medications can effectively improve sleep quality, cognitive impairment and somatization symptom and reduce suicidal ideation in elderly patients with depression.关键词
重复经颅磁刺激/老年抑郁症/临床症状/自杀意念/治疗效果评价Key words
depression/elderly patients/transcranial magnetic stimulation/clinical symptoms/suicidal ideation引用本文复制引用
秦碧勇,戴立磊,郑艳..重复经颅磁刺激对老年抑郁症患者临床症状及自杀意念的疗效[J].南方医科大学学报,2017,37(1):97-101,5.基金项目
湖北省教育厅人文社科科学研究项目（16Q193）；北省教育厅科学技术研究项目 （）
