南方医科大学学报2017，Vol.37Issue(1)：138-141,4.DOI:10.3969/j.issn.1673-4254.2017.01.26
以GSK-3β为靶标的miRNAs调控肝细胞癌侵袭转移的研究进展
Research progress of miRNAs targeting GSK-3β in regulation of hepatocellular carcinoma invasion and metastasis
摘要
Abstract
Invasion and metastasis are key factors contributing to the high mortality rate of patients with hepatocellular carcinoma (HCC) involving a complex mechanism. In the invasion and metastasis of HCC, miRNAs can serve as either oncogenes or tumor suppressor genes to regulate the differentiation and proliferation of tumor cells being and play important roles in tumorigenesis, angiogenesis, invasion and metastasis. This review summarizes the recent progress in research of the molecular mechanisms by which miRNAs targeting GSK-3βregulate HCC invasion and metastasis and examines the roles of miRNAs in hepatocellular carcinoma cell proliferation, apoptosis, invasion, metastasis, and GSK-3βregulation.关键词
肝细胞癌/侵袭转移/miRNAs/综述Key words
hepatocellular carcinoma/invasion and metastasis/miRNAs引用本文复制引用
贺松其,文彬,陈冠新,孙海涛,孙嘉玲,杨雪梅..以GSK-3β为靶标的miRNAs调控肝细胞癌侵袭转移的研究进展[J].南方医科大学学报,2017,37(1):138-141,4.基金项目
国家自然科学基金（81573808）；广东省中医药局课题（20151038） Supported by National Natural Science Foundation of China (81573808) （81573808）
