肝胆胰外科杂志2017，Vol.29Issue(1)：46-50,5.DOI:10.11952/j.issn.1007-1954.2017.01.011
胆囊癌组织中TROP2、PTEN和p-AKT的表达及其临床意义
Clinical value of TRoP2, PTEN and p-AKT expression in gallbladder carcinoma
摘要
Abstract
objective To explore the relationship and clinical significance of human trophoblast cell-surface antigen 2 (TROP2), phosphatase and tensin homolog (PTEN), phosphorylated protein kinase B (p-AKT) in gall-bladder carcinoma. Methods A tatal of 71 patients with gallbladder carcinoma in our hospital were selected be-tween Jan. 2003 and Dec. 2009. Immunohistochemical staining method was used to detected the protein expres-sion of TROP2, PTEN and p-AKT in 71 cases of gallbladder carcinoma tissues and 15 cases of tumor adjacent tissues, Pearson chi-square test was used to analyze the relationship between the protein expression of TROP2, PTEN, p-AKT and the clinical pathological parameters, Spearman test was used to detect the relationship among TROP2, PTEN and p-AKT. Results (1)Compared with the tumor adjacent tissues, the protein expression of TROP2 and p-AKT in gallbladder carcinoma tissues were significantly increased (P<0.05), while the protein ex-pression of PTEN in gallbladder carcinoma tissues was significantly decreased (P<0.05); (2)The proteins expres-sion of TROP2, PTEN and p-AKT were independent with the gender and age (P>0.05), but which was correlated with gallstones, tumor differentiation, organ invasion, depth of invasion and TNM stage (P<0.05); (3)The protein expression of TROP2 was positively correlated with p-AKT (P<0.05), but which was negatively corelated with PTen (P<0.05). Conclusion Abnormal activation of TROP2/PTEN/p-AKT signal pathway may play an impor-tant role in malignant progression of gallbladder carcinoma, the mechanism may be related to TROP2 negative regulation of PTEN expression, inhibiting its dephosphorylation, resulting in increased expression of p-AKT, and promoting the proliferation and metastasis of gallbladder cancer cells. It is an important cause for malignant pro-gression of gallbladder carcinoma, which provides a theoretical basis for clinical targeted intervention studies.关键词
胆囊癌/人滋养层细胞表面抗原-2/磷酸酶与张力蛋白同源物/磷酸化蛋白激酶B/免疫组化分析/预后Key words
gallbladder carcinoma/human trophoblast cell-surface antigen 2 (TROP2)/phosphatase and ten-sin homolog (PTEN)/phosphorylated protein kinase B (p-AKT)/immunohistochemical staining/prognosis分类
医药卫生引用本文复制引用
滕世峰,李新星,张言言,张卫刚,张宪文,姚骏,姚厚山,黄歆,胡志前..胆囊癌组织中TROP2、PTEN和p-AKT的表达及其临床意义[J].肝胆胰外科杂志,2017,29(1):46-50,5.基金项目
国家青年科学基金项目（8140101730）。 （）
