国际医药卫生导报2017，Vol.23Issue(3)：304-306,314,4.DOI:10.3760/cma.j.issn.1007-1245.2017.03.003
盐酸氨基葡萄糖联合阿仑膦酸钠治疗老年膝骨关节炎的疗效及不良反应情况
Effect and adverse reactions of glucosamine hydrochloride and ALN in treatment of senile knee osteoarthritis
摘要
Abstract
Objective To investigate the effect and adverse reactions of glucosamine hydrochloride and ALN for senile knee osteoarthritis.Methods 70 cases of senile knee osteoarthritis treated at our hospital from November,2012 to July,2016 were selected and divided into an observation group (n=35) and a control group (n=35).Both group were treated with glucosamine hydrochloride;in addition,the observation group were treat with ALN;both groups were treated for 7 weeks.The total efficacy,MDA,SOD,lequesne,and adverse reactions were compared between these two groups before and 7 weeks after treatment.Results The total efficacy was 88.57％ (31/35) in the observation group and was 65.71％ (23/35) in the control group,with a statistical difference (x2=5.185,P ＜ 0.05).7 weeks after treatment,the MDA and SOD of the observation group [(4.42±1.52) nmol/ml and (131.15±16.68) nU/ml)] were better than those of the control group [(6.87±1.84) nmol/ml and (112.24±14.24) nU/ml],with statistical differences (P ＜ 0.05).7 weeks after treatment,the scores of stepping ability,joint morning stiffness,arthrocele,articular pain,kinesalgia,and rest pain of the observation group [(1.02±0.42),(0.40±0.14),(0.36±0.11),(0.72±0.24),(1.16±0.31),and (0.33±0.14)] were lower than those of the control group [(1.87±0.49),(0.88±0.25),(0.72±0.26),(1.17±0.25),(2.00±0.49),(1.78±0.26)],with statistical differences (P ＜ 0.05).The incidence of adverse reactions was 8.57％ (3/35) in the control group and was 14.29％ (5/35) in the observation group,with no statistical difference (P ＞ 0.05).Conclusion Glucosamine hydrochloride and ALN for senile knee osteoarthritis can improve oxidation resistance and knee joint function and is safe,so it is worth being generalized.关键词
盐酸氨基葡萄糖/老年膝骨关节炎/阿仑膦酸钠Key words
Glucosamine hydrochloride/Senile knee osteoarthritis/ALN引用本文复制引用
彭璐璐..盐酸氨基葡萄糖联合阿仑膦酸钠治疗老年膝骨关节炎的疗效及不良反应情况[J].国际医药卫生导报,2017,23(3):304-306,314,4.基金项目
郑州市科技局基金资助项目(20150138)Project Supported by Fund of Zhengzhou Scintific Bureau(20150138) （20150138）
