国际医药卫生导报2017，Vol.23Issue(3)：322-325,4.DOI:10.3760/cma.j.issn.1007-1245.2017.03.008
TGF-β1、Smad4、Smad7在口腔鳞癌组织中的表达及临床意义
Expressions of TGF-β1, Smad4, and Smad7 in tissue of oral squamous cell carcinoma and the clinical significance
李文友 1宋丽芳 1李天翔 1张丽 1孙晓宇 1于彦领1
作者信息
- 1. 264400 威海市中心医院口腔颌面外科
- 折叠
摘要
Abstract
Objective To analyze the expressions ofTGF-β1,Smad4,and Smad7 in the tissure of oral squamous cell carcinoma (OSCC) and its relationship with the clinical features of OSCC,to further explore the roles of TGF-β1/Smad4 or Smad7 signaling pathways in the formation and development of OSCC,and to provide a theoretical basis for the diagnosis and treatment of OSCC.Methods 62 patients with OSCC treated at our hospital from March,2013 to February,2016 were collected.The specimens of OSCC and adjacent normal mucosa tissue were collected.The expressions ofTGF-β1,Smad4,and Smad7 in the specimens were determined by immunohistochemical method.The relationship between them and the clinical features of OSCC was analyzed.Results The positive expression rates of TGF-β1 and Smad7 were significantly higher and the positive expression rate of Smad4 was significantly lower in OSCC tissue than in adjacent normal mucosa tissue (P ＜ 0.05).The positive expression rates of TGF-β1 and Smad7 in OSCC increased with the pathological grade of OSCC and with the decrease of OSCC differentiation.The positive expression rates of TGF-β1 and Smad7 were significantly higher in the patients with lymph node metastasis than in the those without (P＜0.05).The positive expression rate of Smad4 decreased with the increase of OSCC pathological grade and with the degree of the differentiation of OSCC;and that of the patients with lymph node metastasis was significantly lower than that that of those without (P ＜ 0.05).Spearman correlation analysis showed that the expression of TGF-β1 in OSCC negatively correlated with the expression of Smad4 (P ＜ 0.05) and positively with the expression of Smad7 (P ＜ 0.05).Conclusions TGF-β1 and Smad7 highly expressed and Smad4 low in OSCC tissues.Therefore,the combined detection of them may be helpful for the diagnosis and treatment of OSCC.关键词
转化生长因子/Smad/口腔鳞癌Key words
Transforming growth factor/Smad/Oral squamous cell carcinoma引用本文复制引用
李文友,宋丽芳,李天翔,张丽,孙晓宇,于彦领..TGF-β1、Smad4、Smad7在口腔鳞癌组织中的表达及临床意义[J].国际医药卫生导报,2017,23(3):322-325,4.
