摘要
Abstract
Objective To investigate the influence of strengthened hypoglycemic and antihypertensive treatment on macrovascular in patients with type 2 diabetes.Methods 120 with patients type 2 diabetes treated at our hospital from December,2010 to December,2014 were set as study objects and were randomly divided into group A,group B,group C,and group D,30 for each group.Group A was given intensive hypoglycemic and antihypertensive treatment,group B intensive glycemic therapy,group C strengthened antihypertensive treatment,and group D general hypoglycemic and antihypertensive treatment.The occurrences of macrovascular disease of the groups were compared and analyzed.Results There were statistical differences in blood glucose indexes and IMT in group A between before and after treatment (t =5.171,6.299,6.448,4.557,P ＜ 0.01).There were statistical differences in systolic and diastolic blood pressures in group A and group C between before and after treatment (t =13.587,9.117,10.694,7.013,P ＜ 0.01) and between those in group A and group C and those in group B and group D after treatment (t =12.229,11.023,10.694,9.859,6.843,6.386,5.988,5.806,P ＜ 0.01).The target-blood-pressure-achieved rate was 83.3％ in group A and was 86.7％ in group C,which were higher than those in group B and group D (x 2=19.461,24.093,21.991,26.786,P ＜ 0.01).1 case (3.3％) got mild vascular disease in group A,15 (50.0％) in group D,10 (33.3％) in group B,and 9 (30.0％) in group C,with statistical the differences between that in group A and those in group B,C,and D (x 2=16.705,9.017,7.680,P ＜ 0.01) but no between group B and group C (x 2=0.077,P ＞ 0.05).Conclusions Intensive hypoglycemic and antihypertensive treatment for type 2 diabetes is more effective than hypoglycemic or antihypertensive treatment and general hypoglycemic and antihypertensive therapy a d can effectively prevent the occurrence of macrovascular disease,so it has high clinical application value.关键词
强化降糖降压/2型糖尿病/大血管病变Key words
Strengthened hypoglycemic and antihypertensive treatment/Type 2 diabetes/Macrovascular
