国际生殖健康计划生育杂志2017，Vol.36Issue(1)：66-69,86,5.
微小RNAs与多囊卵巢综合征发病机制的研究进展
Involvement of MiRNAs in Pathogenesis of Polycystic Ovary Syndrome
摘要
Abstract
MicroRNAs(miRNAs) participate in the regulation of gene expression at the post-transcriptional level. The pathogenesis of polycystic ovary syndrome (PCOS) as a heterogeneous disorder is not clear at present. Abnormal expressions of miRNAs in serum, the follicular fluid and granulosa cells of PCOS patients suggested that miRNAs could contribute to the pathogenesis of PCOS. MiRNAs are closely related to the synthesis and secretion of steroid hormones. MiRNAs were found to be involved in the development and atresia of follicles and thus affect the ovulation process in PCOS patients. MiRNAs also play an important role in the insulin resistance of PCOS patients. MiR-125b, miR-483 and miR-320 affect multiple signaling pathways by regulating multiple target genes. This article reviews the roles of miRNAs in the pathogenesis of PCOS. With the detailed function study in future, some miRNAs could be developed as potential biological markers for the diagnosis and prognosis of PCOS, and as new targets for biological treatment of PCOS.关键词
微RNAs/多囊卵巢综合征/性腺甾类激素/卵泡发育/胰岛素抗药性Key words
MicroRNAs/Polycystic ovary syndrome/Gonadal steroid hormones/Follicular development/Insulin resistance引用本文复制引用
肖华,应小燕,许波群..微小RNAs与多囊卵巢综合征发病机制的研究进展[J].国际生殖健康计划生育杂志,2017,36(1):66-69,86,5.基金项目
国家自然科学基金青年科学基金 （）
