国际口腔医学杂志2017，Vol.44Issue(1)：98-102,5.DOI:10.7518/gjkq.2017.01.020
辅助性T细胞亚群与牙周炎的免疫损伤机制
The role of help T cells in periodontal immunoresponses and tissue destruction
许丽华 1许尧生 2杨冬茹1
作者信息
- 1. 河北医科大学口腔医院口腔内科 石家庄050017
- 2. 衡水哈励逊国际和平医院耳鼻喉科 衡水050030
- 折叠
摘要
Abstract
Periodontal tissue destruction in periodontitis is primarily caused by the immunoresponse and inflammation toward bacterial challenge. T helper(Th) cells are important for the cellular immunity of T cells. In particular, Th2 cells are important for the humoral immunity of B cells. Th1/Th2 is a pair of important effector T cells, which inhibit each other in function by the different cytokines they secrete and keep balance in normal conditions. Previous findings demonstrate that the different clinical manifestations of periodontitis at different periods are associated with Th1/Th2 imbalance. The early and stable period of periodontitis is dominated by Th1 immunoresponses, whereas the progressive period of the disease is dominated by Th2 immunoresponses. The recently found Th17 and regulatory T cell(Treg) are new T helper cell subsets. Th17 cells are associated with chronic periodontal inflammation and tissue destruction, whereas Treg cells are associated with the inhibition of inflammation. Similar to the case of Th1/Th2 balance pattern, Th17 and Treg are also closely related, and they balance each other both in terms of differentiation and functions. Th17/Treg and Th1/Th2 and their cytokines constitute a complicated cytokine network at the periodontal tissue. Their relationship with the progression and tissue destruction of periodontitis is currently undergoing extensive research.关键词
牙周炎/辅助性T细胞亚群/免疫反应Key words
periodontitis/help T cell/immunoresponses分类
生物科学引用本文复制引用
许丽华,许尧生,杨冬茹..辅助性T细胞亚群与牙周炎的免疫损伤机制[J].国际口腔医学杂志,2017,44(1):98-102,5.
